Evidence map›Paper›PMID 38261247›Full record

ArticleCell biochemistry and biophysics2024

Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway.

Lei Xu, Chunfang Zhang, Jiawu Bao, Guozhu Han, Changyuan Wang, Yuanqing Cai, Gang Xu, Huijun Sun, Mozhen Liu

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Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lei Xu *Office of Ethics Committee, the First Affiliated Hospital, Dalian Medical University, Dalian, China.
Chunfang Zhang *Department of Pathology, the First Affiliated Hospital, Dalian Medical University, Dalian, China.
Jiawu BaoDepartment of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Guozhu HanDepartment of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Changyuan WangDepartment of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Yuanqing CaiDepartment of Orthopaedics, the First Affiliated Hospital, Dalian Medical University, Dalian, China.
Gang XuDepartment of Orthopaedics, the First Affiliated Hospital, Dalian Medical University, Dalian, China.
Huijun SunDepartment of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China. sunhuijun@dmu.edu.cn.
Mozhen LiuDepartment of Orthopaedics, the First Affiliated Hospital, Dalian Medical University, Dalian, China. mozhenliu@dmu.edu.cn.
Dalian Medical University · CNFirst Affiliated Hospital of Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to characterize the bone-protecting effects of Alpha-lipoic acid (ALA), a potent antioxidant, against the detrimental effects of the coexistence of type 2 diabetes mellitus (T2DM) and postmenopausal osteoporosis (POP) and identify the possible mechanisms with particular reference to its modulation of YAP/Glut4 pathway. The T2DM and POP coexisting model was induced in mice by high fat diet (HFD) + Streptozocin (STZ) + ovariectomy (OVX). The mice in the treatment groups were given ALA for 10 weeks. In the in vitro study, MC3T3-E1 cells were induced with 500 μM methylglyoxal for 24 h with or without pretreatment with ALA for 24 h. The oxidative and antioxidative biomarkers, bone microarchitecture, histo-morphology, and related protein expression of apoptosis, osteogenic differentiation and the YAP/Glut4 pathway were detected. The results showed ALA could improve glucose tolerance, inhibit oxidative stress and apoptosis and alleviate bone loss. Further study by siRNA technology revealed that the YAP/Glut4 pathway was implicated in the pathogenesis of bone loss due to the coexistence of T2DM and POP. Taken together, the present study has demonstrated for the first time that ALA exerts potent protective effects against bone loss in T2DM and POP coexisting conditions by modulating the YAP/Glut4 pathway.

Indexed as

Diabetes Mellitus, Type 2Glucose Transporter Type 4Osteoporosis, PostmenopausalOxidative StressThioctic AcidYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAnimalsAntioxidantsApoptosisCell DifferentiationCell LineDiabetes Mellitus, ExperimentalDiet, High-FatFemaleHumansAdaptor Proteins, Signal TransducingAntioxidantsGlucose Transporter Type 4Thioctic AcidTranscription FactorsYap1 protein, mouseYAP-Signaling ProteinsAlpha-lipoic acidAntioxidantPostmenopausal osteoporosisType 2 diabetes mellitusYAP/Glut4 pathway

Identifiers

PMID38261247
OpenAlexW4391145192

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.