Evidence map›Paper›PMID 38261232›Full record

ReviewCurrent pain and headache reports2024

Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment.

Christy S Niemeyer, Michael Harlander-Locke, Andrew N Bubak, Rachael Rzasa-Lynn, Marius Birlea

Open access · hybridAbstract readReview
In one paragraph

Review in Current pain and headache reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. [Safety and efficacy of pulsed radiofrequency therapy for zoster-associated trigeminal neuralgia under general anesthesia].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Efficacy of Extracorporeal Shockwave Therapy for Postherpetic Neuralgia.Pain practice : the official journal of World Institute of Pain · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christy S NiemeyerDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Michael Harlander-LockeDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Andrew N BubakDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Rachael Rzasa-LynnDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Marius BirleaDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Marius.Birlea@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · US

Funding

VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2009 to 2023
$30.3M
Pathogenic exosomes during herpes zoster mediate increased vascular dementia riskR01AG085406 · NIA · UNIVERSITY OF COLORADO DENVER · PI Andrew N Bubak · 2024 to 2026
$3.2M
Remote cellular reprogramming by non-infectious, pathogenic varicella zoster virus exosomesR21AI176110 · NIAID · UNIVERSITY OF COLORADO DENVER · PI BUBAK, ANDREW N · 2024 to 2025
$429k
NIAID NIH HHS R21 AI176110NIA NIH HHS P01 AG032958NIA NIH HHS R01 AG085406
6 · The paper itself

Abstract

purpose of reviewTrigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the trigeminal nerve. It poses significant challenges due to its persistent and debilitating nature. This review explores the clinical characteristics of TG-PHN, analyzes its pathophysiological underpinnings, and addresses existent and potential therapies. RECENT

findingsTG-PHN is one of the most common and complex PHN locations. It has distinguishing clinical and pathophysiological characteristics, starting with viral triggered injuries to the trigeminal ganglion (TG) and peripheral tissue and involving the ascending and descending brain modulation pathways. Current therapies include vaccines, oral and topical medications, and interventional approaches, like nerve blocks and neurostimulation. This review covers TG-PHN's clinical and physiological components, treatment options, and potential future targets for improved management. By exploring the complexities of this condition, we aim to contribute to developing more effective and targeted therapies for patients suffering from trigeminal PHN.

Indexed as

Herpes ZosterNerve BlockNeuralgiaNeuralgia, PostherpeticTrigeminal NeuralgiaHumansNeuralgiaPainPostherpeticTrigeminalVirusZoster

Identifiers

PMID38261232
PMCPMC10940365
OpenAlexW4391138939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.