Evidence map›Paper›PMID 38261061›Full record

ArticlePediatric cardiology2024

Cognitive Functioning and Psychosocial Outcomes in Adults with Complex Congenital Heart Disease: A Cross-sectional Pilot Study.

Charlotte E Verrall, Derek L Tran, Nadine A Kasparian, Tracey Williams, Vincent Oxenham, Julian Ayer, David S Celermajer, Rachael L Cordina

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Charlotte E VerrallThe University of Sydney School of Medicine, Sydney, NSW, Australia. charlotte.verrall@sydney.edu.au.
Derek L TranThe University of Sydney School of Medicine, Sydney, NSW, Australia.
Nadine A KasparianHeart and Mind Wellbeing Center, Heart Institute and Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Tracey WilliamsKids Rehab, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Vincent OxenhamSchool of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Julian AyerThe University of Sydney School of Medicine, Sydney, NSW, Australia.
David S CelermajerThe University of Sydney School of Medicine, Sydney, NSW, Australia.
Rachael L CordinaThe University of Sydney School of Medicine, Sydney, NSW, Australia.
Children's Hospital at Westmead · AURoyal Prince Alfred Hospital · AUUniversity of Sydney · AUCincinnati Children's Hospital Medical Center · USRoyal North Shore Hospital · AU

Funding

Medical Research Future Fund - Cardiovascular Health Mission ARGCHDG000016NSW Health Cardiovascular Research Capacity Program H21/174585
6 · The paper itself

Abstract

Adults with complex congenital heart disease (CHD) are at risk for cognitive dysfunction. However, associations between cognitive dysfunction and psychosocial outcomes are poorly defined. Between June and November 2022, we prospectively recruited 39 adults with complex CHD who completed a computerized cognitive assessment (Cogstate) and validated psychosocial scales measuring psychological distress, health-related quality of life (HRQOL), and resilience. Participants had a mean age of 36.4 ± 11.2 years. Over half (62%) were women, most (79%) had complex biventricular CHD, and 21% had Fontan physiology. Prevalence of cognitive dysfunction was greatest in the domains of attention (29%), working memory (25%), and psychomotor speed (21%). Adjusting for age and sex, Pearson partial correlations between Cogstate z-scores and self-reported cognitive problems were small. Participants who lived in the most disadvantaged areas and those with a below-average annual household income had lower global cognitive z-scores (p = 0.02 and p = 0.03, respectively). Two-thirds (64%) reported elevated symptoms of depression, anxiety, and/or stress. Small correlations were observed between psychological distress and cognitive performance. Greater resilience was associated with lower psychological distress (r ≥ -0.5, p < 0.001) and higher HRQOL (r = 0.33, p = 0.02). Our findings demonstrate that adults with complex CHD have a high risk of cognitive dysfunction, though may not recognize or report their cognitive challenges. Lower socioeconomic status may be an indicator for those at risk of poorer cognitive functioning. Psychological distress is common though may not be a strong correlate of performance-based cognitive functioning. Formal cognitive evaluation in this patient population is essential. Optimizing resilience may be a protective strategy to minimize psychological distress and bolster HRQOL.

Indexed as

Heart Defects, CongenitalQuality of LifeAdultCognitionCross-Sectional StudiesFemaleHumansMaleMiddle AgedPilot ProjectsAdult congenital heart diseaseCognitionPsychological distressPsychosocial functioningQuality of lifeResilience

Identifiers

PMID38261061
PMCPMC10891231
OpenAlexW4391137954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.