Evidence map›Paper›PMID 38261059›Full record

Observational studyAging clinical and experimental research2024

Muscle weakness is more strongly associated with functional outcomes in patients with stroke than sarcopenia or muscle wasting: an observational study.

Masafumi Nozoe, Hiroki Kubo, Miho Yamamoto, Rio Ikeji, Haruka Seike, Kazuki Majima, Shinichi Shimada

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Prevalence of Stroke-Related Sarcopenia: A Systematic Review and Meta-Analysis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Pooled it
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  5. NutrigramFrontiers in nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Masafumi NozoeDepartment of Physical Therapy, Faculty of Rehabilitation, Kansai Medical University, 18-89 Uyamahigashicho, Hirakata, Osaka, Japan. masafumi.nozoe@gmail.com.ORCID http://orcid.org/0000-0002-5579-2258
Hiroki KuboDepartment of Physical Therapy, Faculty of Nursing and Rehabilitation, Konan Women's University, Kobe, Japan.
Miho YamamotoDepartment of Rehabilitation Medicine, Nishiyamato Rehabilitation Hospital, Nara, Japan.
Rio IkejiDepartment of Rehabilitation, Itami Kousei Neurosurgical Hospital, Itami, Japan.
Haruka SeikeDepartment of Rehabilitation, Itami Kousei Neurosurgical Hospital, Itami, Japan.
Kazuki MajimaDepartment of Rehabilitation, Itami Kousei Neurosurgical Hospital, Itami, Japan.
Shinichi ShimadaDepartment of Neurosurgery, Itami Kousei Neurosurgical Hospital, Itami, Japan.
Itami City Hospital · JPHebei Rehabilitation Hospital · JPKansai Medical University · JPKonan Women's University · JP

Funding

Japan Society for the Promotion of Science London 21K11182
6 · The paper itself

Abstract

backgroundStroke-related sarcopenia is an important prognosis factor and an intervention target for improving outcomes in patients with stroke.

aimThis study aimed to identify the association between sarcopenia, possible sarcopenia, muscle weakness, muscle mass and calf circumference, and the functional outcomes 3 months after stroke.

methodsIn this single-centre prospective observational study, muscle strength, muscle mass, and calf circumference were measured in patients with acute stroke at hospital discharge. Diagnosis of sarcopenia, possible sarcopenia, muscle weakness, low muscle mass, and low calf circumference were defined according to the 2019 Asian Working Group for Sarcopenia criteria. The primary outcome measure was the modified Rankin Scale (mRS) score at 3 months, with an mRS score of 3 or higher indicating a poor outcome. Logistic regression analysis was conducted to examine independent associations between each assessment and functional outcomes.

resultsA total of 247 patients (median age: 73 years) were included in this study. The prevalence of sarcopenia was 28% (n = 70), and in the adjusted model, sarcopenia (aOR = 2.60, 95% CI 1.07-6.31, p = 0.034), muscle weakness (aOR = 3.40, 95% CI 1.36-8.52, p = 0.009), and low muscle mass (aOR = 2.61, 95% CI 1.04-6.52) were significantly associated with poor functional outcome. Nevertheless, other evaluations did not demonstrate an independent association with the outcome.

conclusionSarcopenia, muscle weakness, and low muscle mass were found to be independently associated with functional outcomes 3 months after stroke, and muscle weakness exhibited the strongest association with outcomes among them.

Indexed as

SarcopeniaStrokeAgedHumansMusclesMuscle WeaknessMuscular AtrophyModified Rankin ScaleMuscle massMuscle weaknessSarcopeniaSarcopenia assessment tool

Identifiers

PMID38261059
PMCPMC10806041
OpenAlexW4391144649

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.