ReviewFrontiers in bioengineering and biotechnology2023
Synergistic antibacterial mechanism of silver-copper bimetallic nanoparticles.
Review in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of antibacterial potential in calcium oxide and silicon oxide nanoparticles for clinical and environmental infection control.Journal of applied biomedicine · 2025Pooled it
- Metal nanoparticles as next-generation therapeutics against antimicrobial resistance: mechanisms, functionalization, and translational potential.Molecular biology reports · 2026Review
- Biofabrication ofRSC advances · 2026Article
- Catalytic conversion of methane to methanol: recent advances in MOF-based catalysts, oxidant strategies, and process optimization.RSC advances · 2026Review
- A review on the controlled preparation, structure-property relationship and application progress of multifunctional metal nanoparticle-based polymer nanocomposites.RSC advances · 2026Review
- Green synthesis of Rhodobryum roseum-mediated ZnO nanoparticles: a multifunctional evaluation of biomedical activities and agricultural applications.Scientific reports · 2026Article
- Sustainable synthesis of bimetallic Cu-Ag nanoparticles using waste-derived chitosan and citrus extract: a green approach to combat antimicrobial resistance.Scientific reports · 2026Article
- Hydrogen production from NaBH₄ hydrolysis over chemically reduced TiO₂-based Ru nanocomposites and their antimicrobial performance.Scientific reports · 2026Article
- Chitosan-Based Aerogel Cushioning Packaging for Improving Postharvest Quality of Wax Apples.Foods (Basel, Switzerland) · 2026Article
- Article
- Iron Oxide-Based Magnetic Nanoparticles in Oral Infection Control.International journal of nanomedicine · 2026Review
- The Role of Silver and Silver-Based Products in Wound Management: A Review of Advances and Current Landscape.Journal of functional biomaterials · 2026Review
- Harnessing biogenic nanoparticles for combating antibiotic resistance: green synthesis, mechanistic insights, and biotechnological applications.Frontiers in bioengineering and biotechnology · 2026Review
- Article
- Metallic nanoparticles in the treatment of staphylococcus infections: a scoping review.BMC pharmacology & toxicology · 2025Article
- Quantitative proteomic and phenotypic responses of urinary pathogens to CuO/Cu₂O nanoparticles.Nanomedicine (London, England) · 2025Article
- Harnessing Copper Nanoparticles for Antimicrobial Applications: Advances and Challenges.Antibiotics (Basel, Switzerland) · 2025Review
- Emerging green-synthesized nanozymes for microbial applications: toward sustainable antimicrobial technologies.World journal of microbiology & biotechnology · 2025Review
- Systematic Nonenzymatic Glucose Detection Using Hydrogel-Protected Ag-Cu/MWCNTs Nanocomposites.ACS omega · 2025Article
- Eco-friendly fabrication of Ag/FeRSC advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The excessive use of antibiotics in clinical settings has resulted in the rapid expansion, evolution, and development of bacterial and microorganism resistance. It causes a significant challenge to the medical community. Therefore, it is important to develop new antibacterial materials that could replace traditional antibiotics. With the advancements in nanotechnology, it has become evident that metallic and metal oxide nanoparticles (MeO NPs) exhibit stronger antibacterial properties than their bulk and micron-sized counterparts. The antibacterial properties of silver nanoparticles (Ag NPs) and copper nanoparticles (Cu NPs) have been extensively studied, including the release of metal ions, oxidative stress responses, damages to cell integrity, and immunostimulatory effects. However, it is crucial to consider the potential cytotoxicity and genotoxicity of Ag NPs and Cu NPs. Numerous experimental studies have demonstrated that bimetallic nanoparticles (BNPs) composed of Ag NPs and Cu NPs exhibit strong antibacterial effects while maintaining low cytotoxicity. Bimetallic nanoparticles offer an effective means to mitigate the genotoxicity associated with individual nanoparticles while considerably enhancing their antibacterial efficacy. In this paper, we presented on various synthesis methods for Ag-Cu NPs, emphasizing their synergistic effects, processes of reactive oxygen species (ROS) generation, photocatalytic properties, antibacterial mechanisms, and the factors influencing their performance. These materials have the potential to enhance efficacy, reduce toxicity, and find broader applications in combating antibiotic resistance while promoting public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.