Evidence map›Paper›PMID 38260702›Full record

ArticlebioRxiv : the preprint server for biology2024

Genomic database furnishes a spontaneous example of a functional Class II glycyl-tRNA synthetase urzyme.

Sourav Kumar Patra, Jordan Douglas, Peter R Wills, Remco Bouckeart, Laurie Betts, Tang Guo Qing, Charles W Carter

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sourav Kumar PatraDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260.ORCID 0000-0002-9314-5641
Jordan DouglasDepartment of Physics, The University of Auckland, New Zealand.
Peter R WillsDepartment of Physics, The University of Auckland, New Zealand.
Remco BouckeartCentre for Computational Evolution, University of Auckland, New Zealand.
Laurie BettsDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260.
Tang Guo QingDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260.
Charles W CarterDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260.
University of North Carolina at Chapel Hill · USUniversity of Auckland · NZ

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
NCI NIH HHS P30 CA016086
6 · The paper itself

Abstract

The chief barrier to studies of how genetic coding emerged is the lack of experimental models for ancestral aminoacyl-tRNA synthetases (AARS). We hypothesized that conserved core catalytic sites could represent such ancestors. That hypothesis enabled engineering functional "urzymes" from TrpRS, LeuRS, and HisRS. We describe here a fourth urzyme, GlyCA, detected in an open reading frame from the genomic record of the arctic fox,

Indexed as

Genomic databasesMinimal catalytic apparatusOrigins of genetic codingReduced coding alphabets

Identifiers

PMID38260702
PMCPMC10802616
OpenAlexW4390859180

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.