Evidence map›Paper›PMID 38260662›Full record

ArticlebioRxiv : the preprint server for biology2024

The brainstem's red nucleus was evolutionarily upgraded to support goal-directed action.

Samuel R Krimmel, Timothy O Laumann, Roselyne J Chauvin, Tamara Hershey, Jarod L Roland, Joshua S Shimony, Jon T Willie, Scott A Norris, Scott Marek, Andrew N Van and 13 more

Registry-linked trialOpen access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Samuel R KrimmelDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-5198-1545
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-0428-427X
Roselyne J ChauvinDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-5786-4705
Tamara HersheyDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Jarod L RolandDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Joshua S ShimonyMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Jon T WillieDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Scott A NorrisDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Scott MarekMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-0032-9052
Andrew N VanDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-8787-0943
Julia MonkDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Kristen M ScheidterDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Forrest WhitingDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nadeshka Ramirez-PerezDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Athanasia MetokiDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Anxu WangMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Benjamin P KayDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Hadas Nahman-AverbuchWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Damien A FairDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Charles J LynchDepartment of Psychiatry, Weill Cornell Medicine, New York, New York, USA.
Marcus E RaichleDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Evan M GordonMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · USMallinckrodt (United States) · USCornell University · USUniversity of Minnesota · US

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASDR01MH096773 · NIMH · UNIVERSITY OF MINNESOTA · PI DOSENBACH, NICO, FAIR, DAMIEN A · 2012 to 2024
$9.4M
BIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8M
Motion-robust brain MRI for infantsR44MH124567 · NIMH · TURING MEDICAL TECHNOLOGIES INC · PI BERTOLERO, MAXWELL, FAIR, DAMIEN A · 2020 to 2023
$7.3M
Efficacy of biomarker-guided rTMS for treatment resistant depressionR01MH118388 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI BHATI, MAHENDRA T, GUNNING, FAITH M · 2019 to 2025
$6.2M
Visual biofeedback to reduce head motion during MRI scansR44MH122066 · NIMH · TURING MEDICAL TECHNOLOGIES INC · PI BRUENER, KEN, FAIR, DAMIEN A · 2019 to 2022
$6.2M
Solving the MRI motion problem with Framewise Integrated Real-Time MRI Monitoring (FIRMM) softwareR44MH121276 · NIMH · TURING MEDICAL TECHNOLOGIES INC · PI FAIR, DAMIEN A, ROTHNEY, MEGAN PEARL · 2020 to 2023
$5.4M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Brain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8M
Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patientsR44NS129521 · NINDS · TURING MEDICAL TECHNOLOGIES INC · PI FAIR, DAMIEN A, KING, KEVIN · 2022 to 2025
$3.7M
The Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0M
NIDA NIH HHS R01 DA047851NIDA NIH HHS T32 DA007261NIDA NIH HHS U01 DA041148NIMH NIH HHS F32 MH120989NIMH NIH HHS K99 MH129616NIMH NIH HHS R00 MH129616NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH115357NIMH NIH HHS R01 MH118388NIMH NIH HHS R01 MH120194NIMH NIH HHS R44 MH121276NIMH NIH HHS R44 MH122066NIMH NIH HHS R44 MH124567NIMH NIH HHS R56 MH114976NIMH NIH HHS T32 MH100019NINDS NIH HHS K12 NS098482NINDS NIH HHS K23 NS088590NINDS NIH HHS K23 NS123345NINDS NIH HHS R01 NS124789NINDS NIH HHS R44 NS129521
6 · The paper itself

Abstract

The red nucleus is a large brainstem structure that coordinates limb movement for locomotion in quadrupedal animals (Basile et al., 2021). The humans red nucleus has a different pattern of anatomical connectivity compared to quadrupeds, suggesting a unique purpose (Hatschek, 1907). Previously the function of the human red nucleus remained unclear at least partly due to methodological limitations with brainstem functional neuroimaging (Sclocco et al., 2018). Here, we used our most advanced resting-state functional connectivity (RSFC) based precision functional mapping (PFM) in highly sampled individuals (n = 5) and large group-averaged datasets (combined

Identifiers

PMID38260662
PMCPMC10802246
OpenAlexW4390484517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.