Evidence map›Paper›PMID 38260660›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of the E3 ubiquitin ligase TRIM67 alters the post-synaptic density proteome.

Laura E McCormick, Natalie K Barker, Laura E Herring, Stephanie L Gupton

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Laura E McCormickDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-2437-8679
Natalie K BarkerMichael Hooker Proteomics Core, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Laura E HerringMichael Hooker Proteomics Core, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Stephanie L GuptonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0003-0087-5432
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Undergraduate Research: Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape ChangeR35GM135160 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Gupton · 2020 to 2026
$3.3M
VASP ubiquitination regulates actin dynamics in dendritic spinesF31NS113381 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCCORMICK, LAURA E · 2019 to 2021
$111k
NCI NIH HHS P30 CA016086NIGMS NIH HHS R35 GM135160NINDS NIH HHS F31 NS113381
6 · The paper itself

Abstract

The E3 ubiquitin ligase TRIM67 is enriched in the central nervous system and is required for proper neuronal development. Previously we demonstrated TRIM67 coordinates with the closely related E3 ubiquitin ligase TRIM9 to regulate cytoskeletal dynamics downstream of the netrin-1 during axon guidance and axon branching in early neuronal morphogenesis. Interestingly, loss of

Indexed as

post-synaptic densityproteomicssynapseTRIM67

Identifiers

PMID38260660
PMCPMC10802379
OpenAlexW4390689515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.