Evidence map›Paper›PMID 38260645›Full record

ArticlebioRxiv : the preprint server for biology2024

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection.

Nathaniel Burman, Svetlana Belukhina, Florence Depardieu, Royce A Wilkinson, Mikhail Skutel, Andrew Santiago-Frangos, Ava B Graham, Alexei Livenskyi, Anna Chechenina, Natalia Morozova and 16 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 4 countries.

Nathaniel BurmanMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.ORCID 0000-0002-3732-3159
Svetlana BelukhinaSkolkovo Institute of Science and Technology, Center for Molecular and Cellular Biology, Moscow, Russia.
Florence DepardieuInstitut Pasteur, Université Paris Cité, CNRS UMR 6047, Synthetic Biology, 75015 Paris, France.
Royce A WilkinsonMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.
Mikhail SkutelSkolkovo Institute of Science and Technology, Center for Molecular and Cellular Biology, Moscow, Russia.
Andrew Santiago-FrangosMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.
Ava B GrahamMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.
Alexei LivenskyiCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia.
Anna ChecheninaSkolkovo Institute of Science and Technology, Center for Molecular and Cellular Biology, Moscow, Russia.
Natalia MorozovaPeter the Great St Petersburg State Polytechnic University, St. Petersburg, Russia.
Trevor ZahlMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.
William S HenriquesMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.ORCID 0000-0001-9836-3827
Murat BuyukyorukMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.
Christophe RouillonInstitut Pasteur, Université Paris Cité, CNRS UMR 6047, Synthetic Biology, 75015 Paris, France.
Lena ShyrokovaDepartment of Experimental Medical Science, Lund University, 221 00 Lund, Sweden.
Tatsuaki KurataDepartment of Experimental Medical Science, Lund University, 221 00 Lund, Sweden.
Vasili HauryliukDepartment of Experimental Medical Science, Lund University, 221 00 Lund, Sweden.ORCID 0000-0003-2389-5057
Konstantin SeverinovWaksman Institute of Microbiology, Piscataway, USA.
Justine GroseilleInstitut Pasteur, CNRS UMR 3525, Université Paris Cité, Unité Régulation Spatiale des Génomes, 75015 Paris, France.
Agnès ThierryInstitut Pasteur, CNRS UMR 3525, Université Paris Cité, Unité Régulation Spatiale des Génomes, 75015 Paris, France.
Romain KoszulInstitut Pasteur, CNRS UMR 3525, Université Paris Cité, Unité Régulation Spatiale des Génomes, 75015 Paris, France.
Florian TessonInstitut Pasteur, Université Paris Cité, Molecular Diversity of Microbes, 75015 Paris, France.
Aude BernheimInstitut Pasteur, Université Paris Cité, Molecular Diversity of Microbes, 75015 Paris, France.
David BikardInstitut Pasteur, Université Paris Cité, CNRS UMR 6047, Synthetic Biology, 75015 Paris, France.
Blake WiedenheftMontana State University, Bozeman, Department of Microbiology and Cell Biology, 59715 Montana, USA.
Artem IsaevSkolkovo Institute of Science and Technology, Center for Molecular and Cellular Biology, Moscow, Russia.ORCID 0000-0002-9593-2745
Montana State University · USCentre National de la Recherche Scientifique · FRSkolkovo Institute of Science and Technology · RULund University · SEInstitut Pasteur · FRLomonosov Moscow State University · RUPeter the Great St. Petersburg Polytechnic University · RU

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI MARK T QUINN · 2012 to 2026
$60.0M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Structural and functional understanding of bacterial defense and viral counter defenseR35GM134867 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Blake A Wiedenheft · 2020 to 2026
$3.8M
Mechanisms of CRISPR-mediated immunity and applications beyond editingK99GM147842 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI SANTIAGO-FRANGOS, ANDREW · 2022 to 2023
$171k
CRISPR RNA-guided recognition of invading RNA activates a multipronged cell death responseF31GM153146 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI BURMAN, NATHANIEL · 2024 to 2025
$73k
NIGMS NIH HHS F31 GM153146NIGMS NIH HHS K99 GM147842NIGMS NIH HHS P20 GM103474NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R35 GM134867
6 · The paper itself

Abstract

Viruses compete with each other for limited cellular resources, and some viruses deliver defense mechanisms that protect the host from competing genetic parasites. PARIS is a defense system, often encoded in viral genomes, that is composed of a 53 kDa ABC ATPase (AriA) and a 35 kDa TOPRIM nuclease (AriB). Here we show that AriA and AriB assemble into a 425 kDa supramolecular immune complex. We use cryo-EM to determine the structure of this complex which explains how six molecules of AriA assemble into a propeller-shaped scaffold that coordinates three subunits of AriB. ATP-dependent detection of foreign proteins triggers the release of AriB, which assembles into a homodimeric nuclease that blocks infection by cleaving the host tRNA

Identifiers

PMID38260645
PMCPMC10802454
OpenAlexW4390656868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.