Evidence map›Paper›PMID 38260625›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of STIM1 and STIM2 in salivary glands disrupts ANO1 function but does not induce Sjogren's disease.

Ga-Yeon Son, Anna Zou, Amanda Wahl, Kai Ting Huang, Manikandan Vinu, Saruul Zorgit, Fang Zhou, Larry Wagner, Youssef Idaghdour, David I Yule and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ga-Yeon Son
Anna Zou
Amanda Wahl
Kai Ting Huang
Manikandan Vinu
Saruul Zorgit
Fang Zhou
Larry Wagner
Youssef IdaghdourORCID 0000-0002-2768-9376
Stefan Feske
Rodrigo S Lacruz
New York University · USUniversity of Rochester · USNew York University Abu Dhabi · AE

Funding

[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR01DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2002 to 2026
$9.9M
Ca2+ signaling via SOCE in the pathogenesis of Sjögren’s syndromeR01DE027981 · NIDCR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN, LACRUZ, RODRIGO S. · 2019 to 2023
$2.7M
NIDCR NIH HHS R01 DE014756
6 · The paper itself

Abstract

Sjogren's disease (SjD) is an autoimmune disease characterized by xerostomia (dry mouth), lymphocytic infiltration into salivary glands and the presence of SSA and SSB autoantibodies. Xerostomia is caused by hypofunction of the salivary glands and has been involved in the development of SjD. Saliva production is regulated by parasympathetic input into the glands initiating intracellular Ca

Identifiers

PMID38260625
PMCPMC10802497
OpenAlexW4390728792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.