Evidence map›Paper›PMID 38260624›Full record

ArticlebioRxiv : the preprint server for biology2024

Connexin43 in mesenchymal lineage cells regulates body adiposity and energy metabolism in mice.

Seung-Yon Lee, Francesca Fontana, Toshifumi Sugatani, Ignacio Portales Castillo, Giulia Leanza, Ariella Coler-Reilly, Roberto Civitelli

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Seung-Yon LeeDepartment of Medicine, Division of Bone and Mineral Diseases; Musculoskeletal Research Center; Washington University School of Medicine, St. Louis, MO. USA.
Francesca FontanaDepartment of Medicine, Division of Bone and Mineral Diseases; Musculoskeletal Research Center; Washington University School of Medicine, St. Louis, MO. USA.ORCID 0000-0002-5889-9413
Toshifumi SugataniDepartment of Medicine, Division of Bone and Mineral Diseases; Musculoskeletal Research Center; Washington University School of Medicine, St. Louis, MO. USA.ORCID 0000-0001-6282-7554
Ignacio Portales CastilloDepartment of Medicine, Division of Bone and Mineral Diseases; Musculoskeletal Research Center; Washington University School of Medicine, St. Louis, MO. USA.
Giulia LeanzaDepartment of Medicine, Division of Bone and Mineral Diseases; Musculoskeletal Research Center; Washington University School of Medicine, St. Louis, MO. USA.ORCID 0000-0001-5489-6613
Ariella Coler-ReillyDepartment of Medicine, Division of Bone and Mineral Diseases; Musculoskeletal Research Center; Washington University School of Medicine, St. Louis, MO. USA.ORCID 0000-0001-8549-6559
Roberto CivitelliDepartment of Medicine, Division of Bone and Mineral Diseases; Musculoskeletal Research Center; Washington University School of Medicine, St. Louis, MO. USA.ORCID 0000-0003-4076-4315
Washington University in St. Louis · US

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
INTERCELLULAR COMMUNICATION IN BONE CELL PHYSIOLOGYR01AR041255 · NIAMS · WASHINGTON UNIVERSITY · PI CIVITELLI, ROBERTO · 1997 to 2017
$5.3M
Skeletal Disorders Training ProgramT32AR060719 · NIAMS · WASHINGTON UNIVERSITY · PI Roberto Civitelli · 2011 to 2026
$4.6M
NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR041255NIAMS NIH HHS T32 AR060719
6 · The paper itself

Abstract

Connexin43 (Cx43) is the most abundant gap junction protein present in the mesenchymal lineage. In mature adipocytes, Cx43 mediates white adipose tissue (WAT) "beiging" in response to cold exposure and maintains the mitochondrial integrity of brown adipose tissue (BAT). We found that genetic deletion of

Identifiers

PMID38260624
PMCPMC10802316
OpenAlexW4390658767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.