Evidence map›Paper›PMID 38260616›Full record

ArticlebioRxiv : the preprint server for biology2024

Disease-associated astrocyte epigenetic memory promotes CNS pathology.

Hong-Gyun Lee, Joseph M Rone, Zhaorong Li, Camilo Faust Akl, Seung Won Shin, Joon-Hyuk Lee, Lucas E Flausino, Florian Pernin, Chun-Cheih Chao, Kilian L Kleemann and 14 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 3 countries.

Joseph M Rone
Zhaorong Li
Camilo Faust Akl
Seung Won Shin
Joon-Hyuk Lee
Lucas E Flausino
Florian Pernin
Chun-Cheih Chao
Kilian L Kleemann
Lena Srun
Tomer Illouz
Federico Giovannoni
Marc Charabati
Liliana M Sanmarco
Jessica E Kenison
Gavin Piester
Stephanie E J ZandeeORCID 0000-0003-0812-676X
Jack Antel
Veit Rothhammer
Michael A Wheeler
Alexandre Prat
Iain C Clark
Francisco J QuintanaORCID 0000-0001-8156-0736
Brigham and Women's Hospital · USBroad Institute · USCentre Hospitalier de l’Université de Montréal · CAMontreal Neurological Institute and Hospital · CAQB3 · USUniversity of Portsmouth · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocytes play important roles in the central nervous system (CNS) physiology and pathology. Indeed, astrocyte subsets defined by specific transcriptional activation states contribute to the pathology of neurologic diseases, including multiple sclerosis (MS) and its pre-clinical model experimental autoimmune encephalomyelitis (EAE)

Identifiers

PMID38260616
PMCPMC10802318
OpenAlexW4390649710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.