Evidence map›Paper›PMID 38260594›Full record

ArticleResearch square2024

HIF1α-glycolysis engages activation-induced cell death to drive IFN-γ induction in hypoxic T cells.

Hongxing Shen, Logan Mullen, Oluwagbemiga A Ojo, Chuan Xing, Abdelrahman Yassin, Zach Lewis, James A Bonner, Lewis Zhichang Shi

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hongxing ShenDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL 35233, USA.ORCID 0000-0001-7400-6809
Logan MullenGenomics Core Laboratory, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, 99775, USA.
Oluwagbemiga A OjoDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL 35233, USA.
Chuan XingDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL 35233, USA.
Abdelrahman YassinDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL 35233, USA.
Zach LewisDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL 35233, USA.
James A BonnerDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL 35233, USA.
Lewis Zhichang ShiDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL 35233, USA.ORCID 0000-0002-5351-8730
University of Alabama at Birmingham · USUniversity of Alabama · USUniversity of Alaska Fairbanks · US

Funding

T cell-intrinsic metabolic control of radiotherapyR01CA279849 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Lewis Z. Shi · 2024 to 2026
$1.2M
Overcoming Tumor-Intrinsic Therapeutic Resistance to ImmunotherapiesR21CA259721 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHI, LEWIS ZHICHANG · 2022 to 2023
$378k
Targeting metabolic checkpoints in the tumor microenvironment to boost efficacy of anti-CTLA-4R21CA230475 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHI, LEWIS ZHICHANG · 2019 to 2020
$355k
NCI NIH HHS R01 CA279849NCI NIH HHS R21 CA230475NCI NIH HHS R21 CA259721
6 · The paper itself

Abstract

The role of HIF1α-glycolysis in regulating IFN-γ induction in hypoxic T cells is unknown. Given that hypoxia is a common feature in a wide array of pathophysiological contexts such as tumor and that IFN-γ is instrumental for protective immunity, it is of great significance to gain a clear idea on this. Combining pharmacological and genetic gain-of-function and loss-of-function approaches, we find that HIF1α-glycolysis controls IFN-γ induction in both human and mouse T cells activated under hypoxia. Specific deletion of HIF1α in T cells (HIF1α

Indexed as

acetate supplementationanaerobic glycolysisHIF1αhypoxiaICBIFN-γT cell

Identifiers

PMID38260594
PMCPMC10802708
OpenAlexW4390822763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.