Evidence map›Paper›PMID 38260592›Full record

ArticlebioRxiv : the preprint server for biology2024

The Emerging Role of 3-Hydroxyanthranilic Acid on

Luis S Espejo, Destiny DeNicola, Leah M Chang, Vanessa Hofschneider, Anne E Haskins, Jonah Balsa, Samuel S Freitas, Angelo Antenor, Sage Hamming, Bradford Hull and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Luis S EspejoMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0001-7800-7876
Destiny DeNicolaMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0003-4679-9180
Leah M ChangMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.
Vanessa HofschneiderMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0009-0003-0832-1079
Anne E HaskinsMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0009-0004-0992-8267
Jonah BalsaMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.
Samuel S FreitasMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-9129-4715
Angelo AntenorMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.
Sage HammingMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.
Bradford HullMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-3614-5119
Raul Castro-PortuguezMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0001-7037-8859
Hope DangMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.
George L SutphinMolecular & Cellular Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-3659-4678
University of Arizona · US

Funding

GRADUATE TRAINING IN BIOCHEMISTRY AND MOLECULAR BIOLOGYT32GM008659 · NIGMS · UNIVERSITY OF ARIZONA · PI CAPALDI, ANDREW PAUL, WEINERT, TED A. · 1997 to 2019
$5.3M
Defining the genetic architecture of multi-stress responseR35GM133588 · NIGMS · UNIVERSITY OF ARIZONA · PI George Lewis Sutphin · 2019 to 2026
$3.0M
Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training ProgramT32AG058503 · NIA · UNIVERSITY OF ARIZONA · PI Kristian Paul Doyle, JANKO Z. NIKOLICH · 2019 to 2026
$1.9M
NIA NIH HHS T32 AG058503NIGMS NIH HHS R35 GM133588NIGMS NIH HHS T32 GM008659
6 · The paper itself

Abstract

3-hydroxyanthranilic acid (3HAA) is considered to be a fleeting metabolic intermediate along tryptophan catabolism through the kynurenine pathway. 3HAA and the rest of the kynurenine pathway have been linked to immune response in mammals yet whether it is detrimental or advantageous is a point of contention. Recently we have shown that accumulation of this metabolite, either through supplementation or prevention of its degradation, extends healthy lifespan in

Identifiers

PMID38260592
PMCPMC10802494
OpenAlexW4390788222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.