Evidence map›Paper›PMID 38260568›Full record

ArticlebioRxiv : the preprint server for biology2024

The functional role of locus coeruleus microglia in the female stress response.

Cora E Smiley, Brittany S Pate, Samantha J Bouknight, Evelynn N Harrington, Aaron M Jasnow, Susan K Wood

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cora E SmileyDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC 29209.
Brittany S PateDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC 29209.
Samantha J BouknightDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC 29209.
Evelynn N HarringtonDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC 29209.
Aaron M JasnowDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC 29209.
Susan K WoodDepartment of Pharmacology, Physiology, and Neuroscience; University of South Carolina School of Medicine, Columbia, SC 29209.
United States Department of Veterans Affairs · USUniversity of South Carolina · US

Funding

Estrogen-mediated mechanisms of stress susceptibilityR01MH113892 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WOOD, SUSAN KATHLEEN · 2018 to 2022
$2.0M
Locus coeruleus-norepinephrine regulation of stress-induced anxiety and opioid reinstatementF32DA058380 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SMILEY, CORA · 2023 to 2024
$146k
Neural Basis of Individual Differences in Fear ExtinctionI01BX001374 · VA · VETERANS HEALTH ADMINISTRATION · PI Marlene A. Wilson · 2013 to 2026
–
Immune basis for hippocampal cholinerginc deficits in pyridostigmine-treated ratsI01BX002664 · VA · VETERANS HEALTH ADMINISTRATION · PI LAWRENCE P REAGAN · 2015 to 2026
–
Neural regulation of susceptibility to hyperarousalI01BX005661 · VA · VETERANS HEALTH ADMINISTRATION · PI Susan Kathleen Wood · 2023 to 2026
–
BLRD VA I01 BX001374BLRD VA I01 BX002664BLRD VA I01 BX005661NIDA NIH HHS F32 DA058380NIMH NIH HHS R01 MH113892
6 · The paper itself

Abstract

Neuropsychiatric disorders that result from stress exposure are highly associated with central inflammation. Our previous work established that females selectively exhibit heightened proinflammatory cytokine production within the noradrenergic locus coeruleus (LC) along with a hypervigilant behavioral phenotype in response to witnessing social stress, and ablation of microglia using pharmacological techniques prevents this behavioral response. These studies were designed to further investigate the impact of stress-induced neuroimmune signaling on the long-term behavioral and neuronal consequences of social stress exposure in females using chemogenetics. We first characterized the use of an AAV-CD68-G

Identifiers

PMID38260568
PMCPMC10802589
OpenAlexW4390765781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.