Evidence map›Paper›PMID 38260567›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens.

Mason Posner, Taylor Garver, Taylor Kaye, Stuart Brdicka, Madison Suttle, Bryce Patterson, Dylan R Farnsworth

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mason PosnerDepartment of Biology and Toxicology, Ashland University, Ashland, OH.ORCID 0000-0003-2817-3395
Taylor GarverDepartment of Biology and Toxicology, Ashland University, Ashland, OH.
Taylor KayeDepartment of Biology and Toxicology, Ashland University, Ashland, OH.
Stuart BrdickaDepartment of Biology and Toxicology, Ashland University, Ashland, OH.
Madison SuttleDepartment of Biology and Toxicology, Ashland University, Ashland, OH.
Bryce PattersonDepartment of Biology and Toxicology, Ashland University, Ashland, OH.
Dylan R FarnsworthThe RNA InsRtute, University at Albany, State University of New York, Albany, NY.
Ashland University · USAlbany State University · US

Funding

Using zebrafish as a model system for investigating lens development, aging and cataract.R15EY013535 · NEI · ASHLAND UNIVERSITY · PI POSNER, MASON · 2001 to 2024
$1.3M
NEI NIH HHS R15 EY013535
6 · The paper itself

Abstract

The vertebrate eye lens is an unusual organ in that most of its cells lack nuclei and the ability to replace aging protein. The small heat shock protein α-crystallins evolved to become key components of this lens, possibly because of their ability to prevent aggregation of aging protein that would otherwise lead to lens opacity. Most vertebrates express two α-crystallins, αA- and αB-crystallin, and mutations in each are linked to human cataract. In a mouse knockout model only the loss of αA-crystallin led to early-stage lens cataract. We have used the zebrafish as a model system to investigate the role of α-crystallins during lens development. Interestingly, while zebrafish express one lens-specific αA-crystallin gene (

Indexed as

AgingCataractChaperoneCrystallinLensscRNA-SeqZebrafish

Identifiers

PMID38260567
PMCPMC10802301
OpenAlexW4390649594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.