Evidence map›Paper›PMID 38260521›Full record

ArticlebioRxiv : the preprint server for biology2024

Mitochondrial membrane potential regulates nuclear DNA methylation and gene expression through phospholipid remodeling.

Mateus Prates Mori, Oswaldo Lozoya, Ashley M Brooks, Dagoberto Grenet, Cristina A Nadalutti, Birgitta Ryback, Kai Ting Huang, Prottoy Hasan, Gyӧrgy Hajnóczky, Janine H Santos

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mateus Prates MoriMechanistic Toxicology Branch, Division of Translational Toxicology.
Oswaldo LozoyaGenome Integrity and Structural Biology Laboratory.
Ashley M BrooksBiostatistics and Computational Biology Branch, Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), 111 TW Alexander drive, Research Triangle Park, NC, 27709.
Dagoberto GrenetMechanistic Toxicology Branch, Division of Translational Toxicology.
Cristina A NadaluttiMechanistic Toxicology Branch, Division of Translational Toxicology.
Birgitta RybackDana Farber Cancer Institute, Harvard Medical School, Boston, MA.
Kai Ting HuangMitoCare Center, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, US.
Prottoy HasanMitoCare Center, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, US.
Gyӧrgy HajnóczkyMitoCare Center, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, US.
Janine H SantosMechanistic Toxicology Branch, Division of Translational Toxicology.
Thomas Jefferson University · USHarvard University · USNational Institutes of Health · US

Funding

ER-mitochondrial communication in calcium signaling, energy metabolism and liver diseaseR01DK125897 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, HAJNOCZKY, GYORGY · 2021 to 2025
$2.7M
Mitochondrial Calcium Uniporter in Signaling and DynamicsR01GM151536 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI Gyorgy Hajnoczky · 2023 to 2026
$1.7M
NIDDK NIH HHS R01 DK125897NIGMS NIH HHS R01 GM151536
6 · The paper itself

Abstract

Maintenance of the mitochondrial inner membrane potential (ΔΨM) is critical for many aspects of mitochondrial function, including mitochondrial protein import and ion homeostasis. While ΔΨM loss and its consequences are well studied, little is known about the effects of increased ΔΨM. In this study, we used cells deleted of

Indexed as

DNA hypermethylationepigenomegene expressionMitochondriamitochondrial membrane potentialphospholipid rewiring

Identifiers

PMID38260521
PMCPMC10802563
OpenAlexW4390859190

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.