Evidence map›Paper›PMID 38260519›Full record

ArticlebioRxiv : the preprint server for biology2024

SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire.

Somen K Mistri, Brianna M Hilton, Katherine J Horrigan, Emma S Andretta, Remi Savard, Oliver Dienz, Kenneth J Hampel, Diana L Gerrard, Joshua T Rose, Nikoletta Sidiropoulos and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Somen K MistriDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.ORCID 0000-0002-2139-6927
Brianna M HiltonDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.
Katherine J HorriganDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.
Emma S AndrettaDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.ORCID 0009-0006-6827-1933
Remi SavardDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.
Oliver DienzDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.ORCID 0000-0001-9380-4873
Kenneth J HampelDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont Medical Center, Burlington, Vermont 05405, USA.
Diana L GerrardDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont Medical Center, Burlington, Vermont 05405, USA.
Joshua T RoseDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont Medical Center, Burlington, Vermont 05405, USA.
Nikoletta SidiropoulosDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont Medical Center, Burlington, Vermont 05405, USA.
Devdoot MajumdarDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.ORCID 0000-0002-2541-3851
Jonathan E BoysonDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.ORCID 0000-0003-2673-9148
University of Vermont · USUniversity of Vermont Medical Center · US

Funding

Acquisition of a new Flow CytometerS10OD026843 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOYSON, JONATHAN E · 2019 to 2019
$204k
Defining the SAP-dependent and SAP-independent gamma delta TCR repertoireR03AI153902 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOYSON, JONATHAN E · 2020 to 2021
$156k
NIAID NIH HHS R03 AI153902NIH HHS S10 OD026843
6 · The paper itself

Abstract

During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair. The mechanisms, however, that regulate γδ T cell developmental programming remain unclear. Recently, we demonstrated that the SLAM-SAP signaling pathway regulates the development and function of multiple innate-like γδ T cell subsets. Here, we used a single-cell proteogenomics approach to identify SAP-dependent developmental checkpoints and to define the SAP-dependent γδ TCR repertoire. SAP deficiency resulted in both a significant loss of an immature

Identifiers

PMID38260519
PMCPMC10802474
OpenAlexW4390819477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.