Evidence map›Paper›PMID 38260480›Full record

ArticleResearch square2024

LOXHD1 is indispensable for coupling auditory mechanosensitive channels to the site of force transmission.

Pei Wang, Katharine K Miller, Enqi He, Siddhant S Dhawan, Christopher L Cunningham, Nicolas Grillet

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Pei WangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA, USA.
Katharine K MillerDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA, USA.
Enqi HeDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA, USA.
Siddhant S DhawanDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA, USA.
Christopher L CunninghamPittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Nicolas GrilletDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA, USA.ORCID 0000-0001-8007-9246
Stanford University · USUniversity of Pittsburgh · US

Funding

Molecular Genetics of Human Age-Related Hearing LossR01AG081608 · NIA · UNIVERSITY OF KENTUCKY · PI Nicolas Grillet · 2023 to 2026
$2.3M
Function of LOXHD1 in mechanosensory hair cellsR01DC016409 · NIDCD · STANFORD UNIVERSITY · PI GRILLET, NICOLAS · 2018 to 2022
$2.1M
High-resolution localization of the hair cell mechanotransduction channel components by immunogold-scanning electronic microscopyR21DC019457 · NIDCD · STANFORD UNIVERSITY · PI GRILLET, NICOLAS · 2021 to 2022
$435k
NIA NIH HHS R01 AG081608NIDCD NIH HHS R01 DC016409NIDCD NIH HHS R21 DC019457
6 · The paper itself

Abstract

Hearing is initiated in hair cells by the mechanical activation of ion channels in the hair bundle. The hair bundle is formed by stereocilia organized into rows of increasing heights interconnected by tip links, which convey sound-induced forces to stereocilia tips. The auditory mechanosensitive channels are complexes containing at least four protein-subunits - TMC1/2, TMIE, CIB2, and LHFPL5

Identifiers

PMID38260480
PMCPMC10802736
OpenAlexW4390508881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.