Evidence map›Paper›PMID 38260478›Full record

ArticleResearch square2024

N-acetylaspartate from fat cells regulates postprandial body temperature.

Jessica B Felix, Pradip K Saha, Evelyn de Groot, Lin Tan, Robert Sharp, Elizabeth S Anaya, Yafang Li, Holly Quang, Nooshin Saidi, Layla Abushamat and 6 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Jessica B FelixDivision of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX.
Pradip K SahaDivision of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX.
Evelyn de GrootDivision of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX.
Lin TanMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Robert SharpDivision of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX.
Elizabeth S AnayaDivision of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX.
Yafang LiDepartment of Medicine, Baylor College of Medicine, Houston, TX.
Holly QuangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine.
Nooshin SaidiData Sciences Program, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD.
Layla AbushamatDepartment of Medicine, Baylor College of Medicine, Houston, TX.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-6432-1730
Christopher I AmosDepartment of Medicine, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-8540-7023
Philip L LorenziMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0003-0385-7774
Samuel KleinCenter for Human Nutrition, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0001-7127-1156
Xia GaoChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine.ORCID 0000-0003-0979-9990
Sean M HartigDivision of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-2695-2072
Baylor College of Medicine · USThe University of Texas MD Anderson Cancer Center · USDuke University · USJohns Hopkins University · USWashington University in St. Louis · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
METABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6M
Metabolic impact of FGF-21 in adipose tissue and liver of PLWHR01DK126042 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LAKE, JORDAN E · 2020 to 2024
$3.4M
Understanding methionine metabolism and its therapeutic potential in cancerR00CA237618 · NCI · BAYLOR COLLEGE OF MEDICINE · PI GAO, XIA · 2022 to 2024
$747k
Baylor College of Medicine Initiative for Maximizing Student DevelopmentT32GM152777 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PANGAS, STEPHANIE A., PEREIRA, FRED A · 2024 to 2024
$547k
Metabolite regulation of adipocyte differentiation in obesityF31DK130596 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FELIX, JESSICA BESERRA · 2022 to 2024
$131k
NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA125123NCI NIH HHS R00 CA237618NIDDK NIH HHS F31 DK130596NIDDK NIH HHS R01 DK114356NIDDK NIH HHS R01 DK126042NIGMS NIH HHS R25 GM056929NIGMS NIH HHS T32 GM152777
6 · The paper itself

Abstract

N-acetylaspartate (NAA), the brain's second most abundant metabolite, provides essential substrates for myelination through its hydrolysis. However, activities and physiological roles of NAA in other tissues remain unknown. Here, we show aspartoacylase (ASPA) expression in white adipose tissue (WAT) governs systemic NAA levels for postprandial body temperature regulation. Proteomics and mass spectrometry revealed NAA accumulation in WAT of

Identifiers

PMID38260478
PMCPMC10802732
OpenAlexW4390759648

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.