Evidence map›Paper›PMID 38260474›Full record

ArticlebioRxiv : the preprint server for biology2024

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets.

John M Bennett, Sunil K Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L Li, Ryan K Muir, Franco F Faucher, Scott Lovell and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

John M BennettDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Sunil K NarwalDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA.
Stephanie KabecheDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
Daniel AbeggDepartment of Chemistry, University of Illinois Chicago, Chicago, IL, USA.
Fiona HackettMalaria Biochemistry Laboratory, Francis Crick Institute, London NW1 1AT, UK.
Tomas YeoDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA.
Veronica L LiDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Ryan K MuirDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Franco F FaucherDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Scott LovellDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Michael J BlackmanMalaria Biochemistry Laboratory, Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-7442-3810
Alexander AdibekianDepartment of Chemistry, University of Illinois Chicago, Chicago, IL, USA.
Ellen YehDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
David A FidockDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA.
Matthew BogyoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3753-4412
Stanford University · USColumbia University Irving Medical Center · USThe Francis Crick Institute · GBUniversity of Illinois Chicago · US

Funding

Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
Probing conformational changes by protein surface azidationR01GM145886 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ADIBEKIAN, ALEXANDER · 2022 to 2025
$1.6M
Parasite-specific proteasome inhibitors to combat multi-drug resistant malariaR33AI127581 · NIAID · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2019 to 2021
$1.4M
Molecular Pharmacology Training GrantT32GM113854 · NIGMS · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2015 to 2019
$1.1M
Mapping Dynamic Changes in Protein Interactome using Proximity Labeling with High Temporal ResolutionR61CA297953 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Alexander Adibekian, ANDREI V KARGINOV · 2025 to 2026
$610k
NCI NIH HHS R61 CA297953NIAID NIH HHS R01 AI109023NIAID NIH HHS R33 AI127581NIGMS NIH HHS R01 GM145886NIGMS NIH HHS T32 GM113854Wellcome Trust CC2129
6 · The paper itself

Abstract

Malaria, caused by

Indexed as

activity-based probesActivity-Based Protein ProfilingDrug Resistancelipid metabolismPlasmodiumserine hydrolases

Identifiers

PMID38260474
PMCPMC10802587
OpenAlexW4390766377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.