In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
19 authors at 1 institution in 1 country.
Maritza Puray-ChavezDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7983-0757 Jenna E EschbachDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9107-4504 Ming XiaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Kyle M LaPakDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7571-4222 Qianzi ZhouDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Ria JasujaDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2984-4827 Jiehong PanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-2384-6845 Jian XuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Zixiang ZhouDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Shawn MohammedDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5189-3713 Qibo WangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Dana Q LawsonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9625-398X Sanja DjokicDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Gaopeng HouDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Siyuan DingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Steven L BrodyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0905-7527 Michael B MajorDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6753-8513 Dennis GoldfarbDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1584-5423 Sebla B KutluayDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5549-7032 Washington University in St. Louis · US
Funding
TRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCERT32CA009547 · NCI · WASHINGTON UNIVERSITY · PI ROBERT DAVID SCHREIBER · 1986 to 2026
$12.1MRole of HIV-1 capsid in innate sensing of viral nucleic acidsF31AI167695 · NIAID · WASHINGTON UNIVERSITY · PI ESCHBACH, JENNA · 2022 to 2024
$101kNCI NIH HHS T32 CA009547NIAID NIH HHS F31 AI167695
6 · The paper itselfAbstract
Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. Here we report that SARS-CoV-2 replication is restricted at a post-entry step in a number of ACE2-positive airway-derived cell lines due to tonic activation of the cGAS-STING pathway mediated by mitochondrial DNA leakage and naturally occurring cGAS and STING variants. Genetic and pharmacological inhibition of the cGAS-STING and type I/III IFN pathways as well as ACE2 overexpression overcome these blocks. SARS-CoV-2 replication in STING knockout cell lines and primary airway cultures induces ISG expression but only in uninfected bystander cells, demonstrating efficient antagonism of the type I/III IFN-pathway in productively infected cells. Pharmacological inhibition of STING in primary airway cells enhances SARS-CoV-2 replication and reduces virus-induced innate immune activation. Together, our study highlights that tonic activation of the cGAS-STING and IFN pathways can impact SARS-CoV-2 cellular tropism in a manner dependent on ACE2 expression levels.
Identifiers
PMID38260460
PMCPMC10802478
OpenAlexW4390769327
What OpenQuestion holds
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LicenceCC BY-NC-ND
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