Evidence map›Paper›PMID 38260442›Full record

ArticleResearch square2024

Cytoplasmic accumulation and plasma membrane association of anillin and Ect2 promote confined migration and invasion.

Avery T Tran, Emily O Wisniewski, Panagiotis Mistriotis, Konstantin Stoletov, Maria Parlani, Alice Amitrano, Brent Ifemembi, Se Jong Lee, Kaustav Bera, Yuqi Zhang and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 3 countries.

Avery T TranDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Emily O WisniewskiDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Panagiotis MistriotisDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.ORCID 0000-0002-8069-3278
Konstantin StoletovDepartment of Oncology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Maria ParlaniDepartment of Medical Biosciences, Radboud University Medical Center, Nijmegen, Netherlands.
Alice AmitranoDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Brent IfemembiDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Se Jong LeeDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Kaustav BeraDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.ORCID 0000-0002-0962-4368
Yuqi ZhangDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Soontorn TuntithavornwatDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Alexandros AfthinosDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.ORCID 0000-0001-6906-0771
Alexander KiepasDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
John J JamiesonDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Yi ZuoJohns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore MD, 21218, USA.
Daniel HabibJohns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore MD, 21218, USA.ORCID 0000-0003-0504-9076
Pei-Hsun WuDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.ORCID 0000-0002-7371-2960
Stuart S MartinMarlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Sharon GerechtDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-8542-4835
Luo GuJohns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore MD, 21218, USA.ORCID 0000-0002-9813-7202
John D LewisDepartment of Oncology, University of Alberta, Edmonton, AB T6G 2E1, Canada.ORCID 0000-0002-7734-1204
Petr KalabDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Peter FriedlDepartment of Medical Biosciences, Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0002-0119-4041
Konstantinos KonstantopoulosDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore MD, 21218, USA.
Johns Hopkins University · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alberta · CADuke University · USUniversity of Maryland, Baltimore · US

Funding

TRANS-NETWORK PROJECTSU54CA143876 · NCI · CORNELL UNIVERSITY · PI SHULER, MICHAEL L · 2009 to 2014
$12.6M
Project 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI SCHAFFER, CHRIS B · 2016 to 2020
$10.2M
Studying E-cadherin dynamics during extravasation and metastatic colonizationU54CA261694 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ROGER D KAMM · 2021 to 2026
$9.1M
Cell mechanoresponses in physiologically relevant microenvironmentsR35GM147101 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI Panagiotis Mistriotis · 2022 to 2026
$2.1M
Cell mechanobiology in confinement using an integration of bioengineering, materials systems and in vivo modelsR01GM142175 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS · 2021 to 2024
$1.8M
NCI NIH HHS U54 CA143876NCI NIH HHS U54 CA210184NCI NIH HHS U54 CA261694NIGMS NIH HHS R01 GM142175NIGMS NIH HHS R35 GM147101
6 · The paper itself

Abstract

Cells migrating in confinement experience mechanical challenges whose consequences on cell migration machinery remain only partially understood. Here, we demonstrate that a pool of the cytokinesis regulatory protein anillin is retained during interphase in the cytoplasm of different cell types. Confinement induces recruitment of cytoplasmic anillin to plasma membrane at the poles of migrating cells, which is further enhanced upon nuclear envelope (NE) rupture(s). Rupture events also enable the cytoplasmic egress of predominantly nuclear RhoGEF Ect2. Anillin and Ect2 redistributions scale with microenvironmental stiffness and confinement, and are observed in confined cells

Identifiers

PMID38260442
PMCPMC10802709
OpenAlexW4390698714

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.