Evidence map›Paper›PMID 38260423›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer.

Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Fei YueLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-6057-0393
Amy T KuLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Payton D StevensDepartment of Cell Biology, Van Andel Institute, Grand Rapids, Michigan, 49503, USA.
Megan N MichalskiDepartment of Cell Biology, Van Andel Institute, Grand Rapids, Michigan, 49503, USA.ORCID 0000-0003-2253-3919
Weiyu JiangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Jianghua TuTexas Therapeutics Institute and Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Zhongcheng ShiAdvanced Technology Cores, Baylor College of Medicine, Houston, Texas 77030, USA.
Yongchao DouLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Yi WangState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Xin-Hua FengLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Galen HostetterVan Andel Institute, Core Technologies and Services, Grand Rapids, Michigan 49503, USA.
Xiangwei WuDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Shixia HuangAdvanced Technology Cores, Baylor College of Medicine, Houston, Texas 77030, USA.
Noah F ShroyerDepartment of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-5934-2852
Bing ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Bart O WilliamsDepartment of Cell Biology, Van Andel Institute, Grand Rapids, Michigan, 49503, USA.
Qingyun LiuTexas Therapeutics Institute and Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Xia LinThe First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, China.
Yi LiLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-9976-518X
Baylor College of Medicine · USVan Andel Institute · USBrown Foundation · USBeijing Proteome Research Center · CNFirst Affiliated Hospital Zhejiang University · CNThe University of Texas MD Anderson Cancer Center · USZhejiang University · CN

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Translational Research in Breast Cancer (SPORE)P50CA186784 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW J ELLIS · 2014 to 2026
$24.5M
Next Generation Rat Models of ER+ Breast CancerR01CA271498 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Yi Li, Xiang Zhang · 2022 to 2026
$3.1M
A Novel LGR4 Oncogenic Signaling in Breast Cancer Progression and MetastasisR01CA204926 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LI, YI · 2017 to 2021
$1.8M
Translational Breast Cancer Research Training ProgramT32CA203690 · NCI · BAYLOR COLLEGE OF MEDICINE · PI FUQUA, SUZANNE AW, RIMAWI, MOTHAFFAR FAHED · 2018 to 2022
$1.0M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Quanterix 2470 Arrayer for Reverse Phase Protein Array TechnologyS10OD028648 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUANG, SHIXIA · 2020 to 2020
$300k
NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA186784NCI NIH HHS R01 CA204926NCI NIH HHS R01 CA271498NCI NIH HHS T32 CA203690NCRR NIH HHS S10 RR024574NIDDK NIH HHS P30 DK056338NIH HHS S10 OD028648
6 · The paper itself

Abstract

ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with

Indexed as

CancerCell signalingEGFRUbiquitination

Identifiers

PMID38260423
PMCPMC10802575
OpenAlexW4390766000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.