Evidence map›Paper›PMID 38260408›Full record

ArticlebioRxiv : the preprint server for biology2024

ABCA7-dependent Neuropeptide-Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer's disease.

Hüseyin Tayran, Elanur Yilmaz, Prabesh Bhattarai, Yuhao Min, Xue Wang, Yiyi Ma, Nastasia Nelson, Nada Kassara, Mehmet Ilyas Cosacak, Ruya Merve Dogru and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 2 countries.

Hüseyin Tayran
Elanur YilmazORCID 0000-0001-7045-5068
Prabesh BhattaraiORCID 0000-0003-2991-5514
Yuhao MinORCID 0000-0001-8775-8743
Xue Wang
Yiyi Ma
Nastasia Nelson
Nada Kassara
Mehmet Ilyas CosacakORCID 0000-0003-2978-3902
Ruya Merve Dogru
Dolly Reyes-Dumeyer
Joseph S ReddyORCID 0000-0002-1783-4453
Min Qiao
Delaney Flaherty
Andrew F TeichORCID 0000-0002-1916-8490
Tamil Iniyan Gunasekaran
Zikun Yang
Giuseppe TostoORCID 0000-0001-7075-8245
Badri N Vardarajan
Özkan İşORCID 0000-0003-4070-6756
Nilüfer Ertekin-TanerORCID 0000-0003-4436-8889
Richard MayeuxORCID 0000-0001-6519-9696
Caghan KizilORCID 0000-0002-8164-9762
Columbia University Irving Medical Center · USJacksonville College · USGerman Center for Neurodegenerative Diseases · DE

Funding

Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious OrderR01AG067501 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2024
$11.7M
NIA NIH HHS R01 AG067501
6 · The paper itself

Abstract

Alzheimer's disease (AD) remains a complex challenge characterized by cognitive decline and memory loss. Genetic variations have emerged as crucial players in the etiology of AD, enabling hope for a better understanding of the disease mechanisms; yet the specific mechanism of action for those genetic variants remain uncertain. Animal models with reminiscent disease pathology could uncover previously uncharacterized roles of these genes. Using CRISPR/Cas9 gene editing, we generated a knockout model for Abstract Figure:

Identifiers

PMID38260408
PMCPMC10802315
OpenAlexW4390656823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.