Evidence map›Paper›PMID 38260393›Full record

ArticlebioRxiv : the preprint server for biology2025

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases.

Yang C Zeng, Olivia J Young, Qiancheng Xiong, Longlong Si, Min Wen Ku, Sylvie G Bernier, Hawa Dembele, Giorgia Isinelli, Tal Gilboa, Zoe Newell Swank and 17 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 14 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 5 institutions in 2 countries.

Yang C ZengDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Olivia J YoungWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Qiancheng XiongDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Longlong SiWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Min Wen KuWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Sylvie G BernierWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Hawa DembeleDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Giorgia IsinelliDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Tal GilboaWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Zoe Newell SwankWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Su Hyun SeokDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Anjali RajwarWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Amanda JiangWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Yunhao ZhaiWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
LaTonya D WilliamsCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina 27701, USA.
Caleb A HellmanCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina 27701, USA.
Chris M WintersingerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Amanda R GravelineWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Andyna VernetWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Melinda SanchezWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Sarai BardalesWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Georgia D TomarasCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina 27701, USA.
Ju Hee RyuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Ick Chan KwonDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Girija GoyalWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
Donald E IngberWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA.
William M ShihDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Harvard University · USInspire Institute · USBoston Children's Hospital · USBrigham and Women's Hospital · USKorea University · KR

Funding

Th1 polarizing immune responses using DNA origamiU54CA244726 · NCI · HARVARD UNIVERSITY · PI HODI, FRANK S, MOONEY, DAVID J · 2019 to 2019
$8.2M
NCI NIH HHS U54 CA244726
6 · The paper itself

Abstract

Current SARS-CoV-2 vaccines have demonstrated robust induction of neutralizing antibodies and CD4

Identifiers

PMID38260393
PMCPMC10802255
OpenAlexW4390656824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.