Evidence map›Paper›PMID 38260385›Full record

ArticleResearch square2024

Novel Anti-B-cell Maturation Antigen Alpha-Amanitin Antibody-drug Conjugate HDP-101 Shows Superior Activity to Belantamab Mafodotin and Enhanced Efficacy in Deletion 17p Myeloma Models.

Ram Kumar Singh, Richard J Jones, Fazal Shirazi, Li Qin, Jianxuan Zou, Samuel Hong, Hua Wang, Hans C Lee, Krina K Patel, Jie Wan and 4 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Ram Kumar SinghThe University of Texas MD Anderson Cancer Center.
Richard J JonesThe University of Texas MD Anderson Cancer Center.
Fazal ShiraziThe University of Texas MD Anderson Cancer Center.
Li QinThe University of Texas MD Anderson Cancer Center.
Jianxuan ZouThe University of Texas MD Anderson Cancer Center.
Samuel HongThe University of Texas MD Anderson Cancer Center.
Hua WangThe University of Texas MD Anderson Cancer Center.
Hans C LeeThe University of Texas MD Anderson Cancer Center.
Krina K PatelThe University of Texas MD Anderson Cancer Center.
Jie WanThe University of Texas MD Anderson Cancer Center.
Rajan Kumar ChoudharyThe University of Texas MD Anderson Cancer Center.
Isere KuiatseThe University of Texas MD Anderson Cancer Center.
Andreas PahlHeidelberg Pharma AG.
Robert Z OrlowskiThe University of Texas MD Anderson Cancer Center.
The University of Texas MD Anderson Cancer Center · USHeidelberg Pharma (Germany) · DE

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Role of Heat Shock Protein 70 as a Mediator and Therapeutic Target in T-cell LymphomasR01CA266612 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Javeed Iqbal, ROBERT ZYGMUNT ORLOWSKI · 2022 to 2026
$2.4M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA266612
6 · The paper itself

Abstract

B-cell maturation antigen (BCMA) plays a pathobiologic role in myeloma and is a validated target with five BCMA-specific therapeutics having been approved for relapsed/refractory disease. However, these drugs are not curative, and responses are inferior in patients with molecularly-defined high-risk disease, including those with deletion 17p (del17p) involving the tumor suppressor

Indexed as

Deletion 17pHDP-101p53proteasome capacityproteasome inhibitor sensitivity

Identifiers

PMID38260385
PMCPMC10802748
OpenAlexW4390754754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.