Evidence map›Paper›PMID 38260362›Full record

ArticlebioRxiv : the preprint server for biology2024

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification.

Jordan Z Zhou, Bihui Huang, Bo Pei, Guang Wen Sun, Michael D Pawlitz, Wei Zhang, Xinyang Li, Kati C Hokynar, Fayi Yao, Madusha L W Perera and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 5 countries.

Jordan Z ZhouDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Bihui HuangDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Bo PeiDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Guang Wen SunSchool of Applied Science, Republic Polytechnic, Singapore 738984, Singapore.
Michael D PawlitzDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Wei ZhangBeijing Genomics Institute (BGI)-Shenzhen, Guangdong 518083, China.
Xinyang LiBeijing Genomics Institute (BGI)-Shenzhen, Guangdong 518083, China.
Kati C HokynarDepartment of Virology, University of Helsinki, Helsinki 00029, Finland.
Fayi YaoDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Madusha L W PereraDepartment of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Shanqiao WeiDepartment of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Simin ZhengSchool of Biological Sciences, Nanyang Technological University, Singapore 636921, Singapore.
Lisa A PolinBarbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University, Detroit, MI 48201, USA.
Janet M PoulikDepartment of Pathology, Children's Hospital of Michigan, Detroit, MI 48201, USA.
Annamari RankiDepartment of Dermatology and Allergic Diseases, University of Helsinki and Helsinki University Hospital, Helsinki 00250, Finland.
Kai KrohnHelsinki University Hospital Research Institute, Biomedicum, Helsinki 00290, Finland.
Charlotte Cunningham-RundlesImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Naibo YangBeijing Genomics Institute (BGI)-Shenzhen, Guangdong 518083, China.
Ashok S BhagwatDepartment of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Kefei YuDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
Pärt PetersonDepartment of Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu 50411, Estonia.
Kai KisandDepartment of Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu 50411, Estonia.
Bao Q VuongDepartment of Biology, City College of New York, New York, NY 10031, USA.ORCID 0000-0001-5416-9635
Andrea CeruttiImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-3026-4704
Kang ChenDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Wayne State University · USBGI Group (China) · CNNanyang Technological University · SGUniversity of Helsinki · FIUniversity of Tartu · EEChildren's Hospital of Michigan · USCity College of New York · USHelsinki University Hospital · FIIcahn School of Medicine at Mount Sinai · USMichigan State University · USNational Institutes of Health · USRepublic Polytechnic · SGSun Yat-sen University · CN

Funding

Human MAIT celis in airway mucosal immune responses to intracellular infectionsU01AI095776 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M. · 2011 to 2015
$8.9M
TRANSCRIPTION--INDUCED MUTATIONSR01GM057200 · NIGMS · WAYNE STATE UNIVERSITY · PI BHAGWAT, ASHOK S · 1998 to 2014
$2.6M
Mechanism of Humoral Immune Defects in Autoimmune Polyglandular Syndrome Type 1R21AI122256 · NIAID · WAYNE STATE UNIVERSITY · PI CHEN, KANG · 2016 to 2017
$419k
NIAID NIH HHS R21 AI122256NIAID NIH HHS U01 AI095776NIGMS NIH HHS R01 GM057200
6 · The paper itself

Abstract

In response to antigens, B cells undergo affinity maturation and class switching mediated by activation-induced cytidine deaminase (AID) in germinal centers (GCs) of secondary lymphoid organs, but uncontrolled AID activity can precipitate autoimmunity and cancer. The regulation of GC antibody diversification is of fundamental importance but not well understood. We found that autoimmune regulator (AIRE), the molecule essential for T cell tolerance, is expressed in GC B cells in a CD40-dependent manner, interacts with AID and negatively regulates antibody affinity maturation and class switching by inhibiting AID function. AIRE deficiency in B cells caused altered antibody repertoire, increased somatic hypermutations, elevated autoantibodies to T helper 17 effector cytokines and defective control of skin

Indexed as

AIDAIREantibody diversificationautoimmunityB cellcheckpointgerminal centerHumoral immunityimmunodeficiencyimmunotherapy

Identifiers

PMID38260362
PMCPMC10802573
OpenAlexW4390787461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.