Evidence map›Paper›PMID 38260314›Full record

ArticlebioRxiv : the preprint server for biology2024

TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility.

Pradeep Rajasekhar, Simona E Carbone, Stuart T Johnston, Cameron J Nowell, Lukasz Wiklendt, Edmund J Crampin, Yinghan She, Jesse J DiCello, Ayame Saito, Luke Sorensen and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Pradeep RajasekharDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0002-1983-7244
Simona E CarboneDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0002-4350-6357
Stuart T JohnstonSchool of Mathematics and Statistics, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0003-4532-5573
Cameron J NowellDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0002-8662-9840
Lukasz WiklendtCollege of Medicine & Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Edmund J CrampinSchool of Mathematics and Statistics, The University of Melbourne, Parkville, VIC 3010, Australia.
Yinghan SheDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Jesse J DiCelloDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Ayame SaitoDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Luke SorensenDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Thanh NguyenDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Kevin Mc LeeDepartment of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3010, Australia.
John A HamiltonDepartment of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3010, Australia.
Sebastian K KingDepartment of Paediatric Surgery, The Royal Children's Hospital, Parkville, VIC 3052, Australia.
Emily M ErikssonPopulation Health and Immunity, WEHI, Parkville, VIC 3052, Australia.ORCID 0000-0002-7851-973X
Nick J SpencerCollege of Medicine & Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Brian D GulbransenDepartment of Physiology, Michigan State University, MI, USA.ORCID 0000-0003-1145-3227
Nicholas A VeldhuisDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0002-8902-9365
Daniel P PooleDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0002-6168-8422
Monash University · AUThe University of Melbourne · AUFlinders University · AUThe Royal Melbourne Hospital · AUMichigan State University · USRoyal Children's Hospital · AU

Funding

Role of enteric glia in the death of neurons during gut inflammationR01DK103723 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2015 to 2026
$4.7M
Enteric glia and visceral painR01DK120862 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2019 to 2026
$3.0M
NIDDK NIH HHS R01 DK103723NIDDK NIH HHS R01 DK120862
6 · The paper itself

Abstract

Background: Mechanosensation is an important trigger of physiological processes in the gastrointestinal tract. Aberrant responses to mechanical input are associated with digestive disorders, including visceral hypersensitivity. Transient Receptor Potential Vanilloid 4 (TRPV4) is a mechanosensory ion channel with proposed roles in visceral afferent signaling, intestinal inflammation, and gut motility. While TRPV4 is a potential therapeutic target for digestive disease, current mechanistic understanding of how TRPV4 may influence gut function is limited by inconsistent reports of TRPV4 expression and distribution. Methods: In this study we profiled functional expression of TRPV4 using Ca Results: The TRPV4 agonist GSK1016790A evoked Ca Conclusions: We reveal a previously unappreciated role for TRPV4 in the initiation of distension-evoked colonic motility. These observations provide new insights into the functional role of TRPV4 activation in the gut, with important implications for how TRPV4 may influence critical processes including inflammatory signaling and motility.

Indexed as

Bioimage analysisCalcium ImagingEnteric Glial CellsMotilityResident MacrophagesTransient Receptor PotentialTRPV4

Identifiers

PMID38260314
PMCPMC10802399
OpenAlexW4390766448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.