Evidence map›Paper›PMID 38260294›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Multi-ancestry polygenic risk scores for venous thromboembolism.

Yon Ho Jee, Florian Thibord, Alicia Dominguez, Corriene Sept, Kristin Boulier, Vidhya Venkateswaran, Yi Ding, Tess Cherlin, Shefali Setia Verma, Valeria Lo Faro and 27 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors.

Yon Ho JeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, MA, USA.ORCID 0000-0003-4686-2186
Florian ThibordPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, MD, USA.
Alicia DominguezDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Corriene SeptDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Kristin BoulierBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Vidhya VenkateswaranDepartment of Oral Biology, University of California Los Angeles School of Dentistry, Los Angeles, CA, USA.
Yi DingBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Tess CherlinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Shefali Setia VermaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Valeria Lo FaroDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.
Anne BolandUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.ORCID 0000-0001-8509-148X
Jean-Francois DeleuzeUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Joseph EmmerichDepartment of Vascular Medicine, Paris Saint-Joseph Hospital Group, University of Paris, Paris, France.
Marine GermainUniversity of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Andrew D JohnsonPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, MD, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinbson Cancer Center, Seattle WA 98109.
Pierre-Emmanuel MorangeAix-Marseille University, INSERM, INRAE, Centre de Recherche en CardioVasculaire et Nutrition, Laboratory of Haematology, CRB Assistance Publique - Hôpitaux de Marseille, HemoVasc, Marseille, France.ORCID 0000-0002-9065-722X
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.
Alexander P ReinerDepartment of Epidemiology, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.
David M SmadjaInnovative Therapies in Hemostasis, Université de Paris, INSERM, F-75006 Paris, France.ORCID 0000-0001-7731-9202
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.
Pierre SuchonAix-Marseille University, INSERM, INRAE, Centre de Recherche en CardioVasculaire et Nutrition, Laboratory of Haematology, CRB Assistance Publique - Hôpitaux de Marseille, HemoVasc, Marseille, France.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, 55454, USA.
David-Alexandre TrégouëtUniversity of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Sebastian ZöllnerDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Bogdan PasaniucDepartment of Oral Biology, University of California Los Angeles School of Dentistry, Los Angeles, CA, USA.
Scott M DamrauerDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Serena SannaUniversity of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.ORCID 0000-0002-3768-1749
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lifelines Cohort Study
Christopher KabrhelCenter for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nicholas L SmithDepartment of Health Systems and Population Health, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.
Peter KraftTransdivisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, USA.
INVENT Consortium

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2M
UCLA Dental Specialty PhD ProgramK12DE027830 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne L Kapila · 2018 to 2026
$1.5M
NCATS NIH HHS UL1 TR001878NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA176726NCI NIH HHS U01 CA261339NCI NIH HHS UM1 CA186107NHGRI NIH HHS T32 HG000040NIDCR NIH HHS K12 DE027830
6 · The paper itself

Abstract

Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with large disparities in incidence rates between Black and White Americans. Polygenic risk scores (PRSs) limited to variants discovered in genome-wide association studies in European-ancestry samples can identify European-ancestry individuals at high risk of VTE. However, there is limited evidence on whether high-dimensional PRS constructed using more sophisticated methods and more diverse training data can enhance the predictive ability and their utility across diverse populations. We developed PRSs for VTE using summary statistics from the International Network against Venous Thrombosis (INVENT) consortium GWAS meta-analyses of European- (71,771 cases and 1,059,740 controls) and African-ancestry samples (7,482 cases and 129,975 controls). We used LDpred2 and PRSCSx to construct ancestry-specific and multi-ancestry PRSs and evaluated their performance in an independent European- (6,261 cases and 88,238 controls) and African-ancestry sample (1,385 cases and 12,569 controls). Multi-ancestry PRSs with weights tuned in European- and African-ancestry samples, respectively, outperformed ancestry-specific PRSs in European- (PRSCSX

Identifiers

PMID38260294
PMCPMC10802635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.