Evidence map›Paper›PMID 38260273›Full record

ArticlebioRxiv : the preprint server for biology2024

Taking identity-by-descent analysis into the wild: Estimating realized relatedness in free-ranging macaques.

Annika Freudiger, Vladimir M Jovanovic, Yilei Huang, Noah Snyder-Mackler, Donald F Conrad, Brian Miller, Michael J Montague, Hendrikje Westphal, Peter F Stadler, Stefanie Bley and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Annika FreudigerBehavioral Ecology Research Group, Faculty of Life Sciences, Institute of Biology, Leipzig University, Leipzig, Germany.ORCID 0000-0003-1795-7944
Vladimir M JovanovicHuman Biology and Primate Evolution, Institut für Zoologie, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0002-8056-5065
Yilei HuangDepartment of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0002-2860-2543
Noah Snyder-MacklerCenter for Evolution & Medicine, School of Life Sciences, Arizona State University, Tempe, USA.ORCID 0000-0003-3026-6160
Donald F ConradDivision of Genetics, Oregon National Primate Research Center, Portland, Oregon, USA.ORCID 0000-0003-3828-8970
Brian MillerDivision of Genetics, Oregon National Primate Research Center, Portland, Oregon, USA.
Michael J MontagueDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0253-4404
Hendrikje WestphalBehavioral Ecology Research Group, Faculty of Life Sciences, Institute of Biology, Leipzig University, Leipzig, Germany.ORCID 0009-0008-5860-5674
Peter F StadlerBioinformatics Group, Institute of Computer Science, and Interdisciplinary Center for Bioinformatics, Leipzig University, Leipzig, Germany.ORCID 0000-0002-5016-5191
Stefanie BleyBehavioral Ecology Research Group, Faculty of Life Sciences, Institute of Biology, Leipzig University, Leipzig, Germany.
Julie E HorvathDepartment of Biological and Biomedical Sciences, North Carolina Central University, North Carolina, Durham, USA.ORCID 0000-0002-6426-035X
Lauren J N BrentCentre for Research in Animal Behaviour, University of Exeter, Exeter, UK.ORCID 0000-0002-1202-1939
Michael L PlattDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Angelina Ruiz-LambidesCayo Santiago Field Station, Caribbean Primate Research Center, University of Puerto Rico, Punta Santiago, Puerto Rico.ORCID 0000-0003-0733-4110
Jenny TungDepartment of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0003-0416-2958
Katja NowickHuman Biology and Primate Evolution, Institut für Zoologie, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0003-3993-4479
Harald RingbauerDepartment of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0002-4884-9682
Anja WiddigBehavioral Ecology Research Group, Faculty of Life Sciences, Institute of Biology, Leipzig University, Leipzig, Germany.ORCID 0000-0003-1772-8770

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Translational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4M
Multispecies NHP dGTEx Research CenterU24HG012483 · NHGRI · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRISTIN ARDLIE, DONALD F. CONRAD · 2022 to 2026
$17.0M
Coordinating center for collaborative marmoset researchU24MH123696 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI DONALD F. CONRAD · 2020 to 2026
$4.6M
Social modifiers of the pace of aging across multiple domains and tissuesR01AG060931 · NIA · UNIVERSITY OF WASHINGTON · PI BRENT, LAUREN JOHANNA NICOLE, HIGHAM, JAMES P · 2019 to 2023
$3.6M
Animal Model of Genetics and Social Behavior in Autism Spectrum DisordersR01MH096875 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PLATT, MICHAEL L · 2012 to 2016
$3.6M
Neurogenomics of Vulnerability and Resilience to Mental Health Syndromes in Response to Extreme Life EventsR01MH118203 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PLATT, MICHAEL L · 2019 to 2023
$1.9M
NHGRI NIH HHS U24 HG012483NIA NIH HHS R01 AG060931NIH HHS P40 OD012217NIH HHS P51 OD011092NIMH NIH HHS R01 MH096875NIMH NIH HHS R01 MH118203NIMH NIH HHS U24 MH123696
6 · The paper itself

Abstract

Biological relatedness is a key consideration in studies of behavior, population structure, and trait evolution. Except for parent-offspring dyads, pedigrees capture relatedness imperfectly. The number and length of DNA segments that are identical-by-descent (IBD) yield the most precise estimates of relatedness. Here, we leverage novel methods for estimating locus-specific IBD from low coverage whole genome resequencing data to demonstrate the feasibility and value of resolving fine-scaled gradients of relatedness in free-living animals. Using primarily 4-6× coverage data from a rhesus macaque (

Indexed as

gradient in relatednessidentity-by-descentlong-term pedigreerhesus macaqueswhole genome resequencing

Identifiers

PMID38260273
PMCPMC10802400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.