ArticleFrontiers in endocrinology2023
Assessment of potential risk factors associated with gestational diabetes mellitus: evidence from a Mendelian randomization study.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
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- Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits.Medicine · 2025Article
- Transplacental transfer efficiency of environmental chemicals in association with gestational diabetes mellitus.Environment international · 2025Article
- Integrating in vitro and in silico approaches for exploring antidiabetic potential of dimethyl and thiomethyl indolinone derivatives.PloS one · 2025Article
- Maternal Iron Levels and Association With Gestational Diabetes: A Systematic Review and Meta-Analysis.Journal of nutrition and metabolism · 2025Review
- Theoretical Study of Gas Sensing toward Acetone by a Single-Atom Transition Metal (Sc, Ti, V, and Cr)-Doped InPACS omega · 2024Article
- Design, synthesis, biological evaluation and computational studies of 4-Aminopiperidine-3, 4-dihyroquinazoline-2-uracil derivatives as promising antidiabetic agents.Scientific reports · 2024Article
- An Exploration of Shared Risk Factors for Coronary Artery Disease and Cancer from 109 Traits: The Evidence from Two-Sample Mendelian Randomization Studies.Reviews in cardiovascular medicine · 2024Article
- Exploring the causal association between epigenetic clocks and menopause age: insights from a bidirectional Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives.Frontiers in cardiovascular medicine · 2024Review
- Environmental endocrine disruptor-induced mitochondrial dysfunction: a potential mechanism underlying diabetes and its complications.Frontiers in endocrinology · 2024Review
- Unveiling the causal link between metabolic factors and ovarian cancer risk using Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
Background: Previous research on the association between risk factors and gestational diabetes mellitus (GDM) primarily comprises observational studies with inconclusive results. The objective of this study is to investigate the causal relationship between 108 traits and GDM by employing a two-sample Mendelian randomization (MR) analysis to identify potential risk factors of GDM. Methods: We conducted MR analyses to explore the relationships between traits and GDM. The genome-wide association studies (GWAS) for traits were primarily based on data from the UK Biobank (UKBB), while the GWAS for GDM utilized data from FinnGen. We employed a false discovery rate (FDR) of 5% to account for multiple comparisons. Results: The inverse-variance weighted (IVW) method indicated that the genetically predicted 24 risk factors were significantly associated with GDM, such as "Forced expiratory volume in 1-second (FEV1)" (OR=0.76; 95% CI: 0.63, 0.92), "Forced vital capacity (FVC)" (OR=0.74; 95% CI: 0.64, 0.87), "Usual walking pace" (OR=0.19; 95% CI: 0.09, 0.39), "Sex hormone-binding globulin (SHBG)" (OR=0.86; 95% CI: 0.78, 0.94). The sensitivity analyses with MR-Egger and weighted median methods indicated consistent results for most of the trats. Conclusion: Our study has uncovered a significant causal relationship between 24 risk factors and GDM. These results offer a new theoretical foundation for preventing or mitigating the risks associated with GDM.
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