ReviewFrontiers in endocrinology2023
Impact of stress on male fertility: role of gonadotropin inhibitory hormone.
Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Exploring the link between periodontal disease and sperm quality: a comprehensive systematic review study.BMC oral health · 2025Pooled it
- The effect of job stress on fertility, its intention, and infertility treatment among the workers: a systematic review.BMC public health · 2025Pooled it
- Terpenes as Potential Multi-Target Modulators of Chronic Stress-Induced Neuroendocrine-Immune Dysregulation.International journal of molecular sciences · 2026Review
- The link between diabetes and male infertility: mechanisms and implications.Scientific reports · 2026Article
- Differential association between perceived social support and andropause symptoms by psychological distress level in employed men.Comprehensive psychoneuroendocrinology · 2026Article
- Chronic Stress Destabilizes Ectoplasmic Specialization Dynamics in the Rat Testis via Downregulating the Focal Adhesion Kinase-Associated Protein Complex.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
- Neuroendocrine effects of exogenous adropin administration on the hypothalamic pituitary testicular axis in male rats.Turkish journal of medical sciences · 2026Article
- The association between depression, perceived stress, and sexual function among adults attending primary health care services.BMC public health · 2025Article
- Determinants of male fertility in the Western Pacific Region: environmental, biological, and lifestyle influences.The Lancet regional health. Western Pacific · 2025Review
- Regional variations in the morphology of the efferent ductules: a histological perspective in rats, bulls, stallions, and boars.BMC veterinary research · 2025Article
- Depression, anxiety, and stress impair sperm quality via dysregulation of the mitochondrial PDK-PDC axis.Reproductive biology and endocrinology : RB&E · 2025Article
- Lifestyle and Environmental Factors Affecting Male Fertility, Individual Predisposition, Prevention, and Intervention.International journal of molecular sciences · 2025Review
- Understanding the intricate impacts and mechanism of actions of adaptogens on reproductive function.Cell biochemistry and biophysics · 2025Review
- From waste to health: exploring the male sexuality enhancing activities of the bioactive components of orange peel.Frontiers in endocrinology · 2025Review
- Can lifestyle changes significantly improve male fertility: A narrative review?Arab journal of urology · 2025Review
- Impact of Ultraviolet C Radiation on Male Fertility in Rats: Suppression of Autophagy, Stimulation of Gonadotropin-Inhibiting Hormone, and Alteration of miRNAs.International journal of molecular sciences · 2025Article
- Effect of Dietary Magnesium on the Association Between Serum Uric Acid and Female Infertility.International journal of women's health · 2025Article
- Vitamin D in male sexual functions: unwrapping the sunshine hormone activities in erectile function and beyond.Frontiers in reproductive health · 2025Review
- Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi.Open veterinary journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have implicated oxidative stress-sensitive signaling in the pathogenesis of stress-induced male infertility. However, apart from oxidative stress, gonadotropin inhibitory hormone (GnIH) plays a major role. The present study provides a detailed review of the role of GnIH in stress-induced male infertility. Available evidence-based data revealed that GnIH enhances the release of corticosteroids by activating the hypothalamic-pituitary-adrenal axis. GnIH also mediates the inhibition of the conversion of thyroxine (T4) to triiodothyronine (T3) by suppressing the hypothalamic-pituitary-thyroidal axis. In addition, GnIH inhibits gonadotropin-releasing hormone (GnRH), thus suppressing the hypothalamic-pituitary-testicular axis, and by extension testosterone biosynthesis. More so, GnIH inhibits kisspeptin release. These events distort testicular histoarchitecture, impair testicular and adrenal steroidogenesis, lower spermatogenesis, and deteriorate sperm quality and function. In conclusion, GnIH, via multiple mechanisms, plays a key role in stress-induced male infertility. Suppression of GnIH under stressful conditions may thus be a beneficial prophylactic and/or therapeutic strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.