Evidence map›Paper›PMID 38260121›Full record

ArticleResuscitation plus2024

Route of drug administration in out-of-hospital cardiac arrest: A protocol for a randomised controlled trial (PARAMEDIC-3).

Keith Couper, Chen Ji, Ranjit Lall, Charles D Deakin, Rachael Fothergill, John Long, James Mason, Felix Michelet, Jerry P Nolan, Henry Nwankwo and 32 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 13 institutions in 1 country.

Keith CouperWarwick Clinical Trials, University of Warwick, Coventry, UK.
Chen JiWarwick Clinical Trials, University of Warwick, Coventry, UK.
Ranjit LallWarwick Clinical Trials, University of Warwick, Coventry, UK.
Charles D DeakinUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Rachael FothergillWarwick Clinical Trials, University of Warwick, Coventry, UK.
John LongWarwick Clinical Trials, University of Warwick, Coventry, UK.
James MasonWarwick Clinical Trials, University of Warwick, Coventry, UK.
Felix MicheletWarwick Clinical Trials, University of Warwick, Coventry, UK.
Jerry P NolanWarwick Clinical Trials, University of Warwick, Coventry, UK.
Henry NwankwoWarwick Clinical Trials, University of Warwick, Coventry, UK.
Tom QuinnKingston University, London, UK.
Anne-Marie SlowtherDivision of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Michael A SmythWarwick Clinical Trials, University of Warwick, Coventry, UK.
Alison WalkerWest Midlands Ambulance Service University NHS Foundation Trust, Brierly Hill, UK.
Loraine ChowdhuryWarwick Clinical Trials, University of Warwick, Coventry, UK.
Chloe NormanWarwick Clinical Trials, University of Warwick, Coventry, UK.
Laurille SprauveWarwick Clinical Trials, University of Warwick, Coventry, UK.
Kath StarrWarwick Clinical Trials, University of Warwick, Coventry, UK.
Sara WoodWarwick Clinical Trials, University of Warwick, Coventry, UK.
Steve BellNorth West Ambulance Service NHS Trust, Bolton, UK.
Gemma BradleyResearch and Development Department, South East Coast Ambulance Service NHS Foundation Trust, Crawley, UK.
Martina BrownSouth Central Ambulance NHS Foundation Trust, Otterbourne, UK.
Shona BrownEast of England Ambulance Service NHS Trust, Melbourn, UK.
Karl CharltonNorth East Ambulance Service NHS Foundation Trust, Newcastle upon Tyne, UK.
Alison CoppolaSouth Western Ambulance Service NHS Foundation Trust, Exeter, UK.
Charlotte EvansWelsh Ambulance Services NHS Trust, Cwmbran, UK.
Christine EvansWest Midlands Ambulance Service University NHS Foundation Trust, Brierly Hill, UK.
Theresa FosterEast of England Ambulance Service NHS Trust, Melbourn, UK.
Michelle JacksonNorth East Ambulance Service NHS Foundation Trust, Newcastle upon Tyne, UK.
Justin KearneyClinical Audit and Research Unit, London Ambulance Service, London, UK.
Nigel LangDevon Air Ambulance Trust, Exeter, UK.
Adam Mellett-SmithWarwick Clinical Trials, University of Warwick, Coventry, UK.
Ria OsborneSouth Western Ambulance Service NHS Foundation Trust, Exeter, UK.
Helen PocockWarwick Clinical Trials, University of Warwick, Coventry, UK.
Nigel ReesWelsh Ambulance Services NHS Trust, Cwmbran, UK.
Robert SpaightEast Midlands Ambulance Service NHS Trust, Nottingham, UK.
Belinda TibbettsDevon Air Ambulance Trust, Exeter, UK.
Gregory A WhitleyEast Midlands Ambulance Service NHS Trust, Nottingham, UK.
Jason WilesWest Midlands Ambulance Service University NHS Foundation Trust, Brierly Hill, UK.
Julia WilliamsResearch and Development Department, South East Coast Ambulance Service NHS Foundation Trust, Crawley, UK.
Adam WrightNorth West Ambulance Service NHS Trust, Bolton, UK.
Gavin D PerkinsWarwick Clinical Trials, University of Warwick, Coventry, UK.
University of Warwick · GBEast Midlands Ambulance Service NHS Trust · GBNorth East Ambulance Service NHS Foundation Trust · GBWelsh Ambulance Services NHS Trust · GBEast of England Ambulance Service NHS Trust · GBHarrogate and District NHS Foundation Trust · GBNorth West Ambulance Service NHS Trust · GBSouth Western Ambulance Service NHS Foundation Trust · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBKingston University · GBLondon Ambulance Service NHS Trust · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Hertfordshire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The PARAMEDIC-3 trial evaluates the clinical and cost-effectiveness of an intraosseous first strategy, compared with an intravenous first strategy, for drug administration in adults who have sustained an out-of-hospital cardiac arrest. Methods: PARAMEDIC-3 is a pragmatic, allocation concealed, open-label, multi-centre, superiority randomised controlled trial. It will recruit 15,000 patients across English and Welsh ambulance services. Adults who have sustained an out-of-hospital cardiac arrest are individually randomised to an intraosseous access first strategy or intravenous access first strategy in a 1:1 ratio through an opaque, sealed envelope system. The randomised allocation determines the route used for the first two attempts at vascular access. Participants are initially enrolled under a deferred consent model.The primary clinical-effectiveness outcome is survival at 30-days. Secondary outcomes include return of spontaneous circulation, neurological functional outcome, and health-related quality of life. Participants are followed-up to six-months following cardiac arrest. The primary health economic outcome is incremental cost per quality-adjusted life year gained. Conclusion: The PARAMEDIC-3 trial will provide key information on the clinical and cost-effectiveness of drug route in out-of-hospital cardiac arrest.Trial registration: ISRCTN14223494, registered 16/08/2021, prospectively registered.

Indexed as

Cardiac arrestClinical trial protocolEpinephrineIntraosseousIntravenous

Identifiers

PMID38260121
PMCPMC10801302
OpenAlexW4390456068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.