Evidence map›Paper›PMID 38259831›Full record

ArticleFrontiers in medicine2023

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice.

Regina Demlova, Sarka Kozakova, Michal Rihacek, Dana Buckova, Katerina Horska, Ondrej Wiewiorka, Lubos Boucek, Iveta Selingerova, Martina Podborska, Alena Korberova and 7 more

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Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Regina Demlova *Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechia.
Sarka Kozakova *Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechia.
Michal RihacekDiagnostic and Therapeutic Centre, Emergency Services Department, University Hospital Brno, Masaryk University, Brno, Czechia.
Dana BuckovaDepartment of Laboratory Medicine, University Hospital Brno, Masaryk University, Brno, Czechia.
Katerina HorskaDepartment of Pharmacy, Clinical Pharmacy Services Unit, University Hospital Brno, Brno, Czechia.
Ondrej WiewiorkaDepartment of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czechia.
Lubos BoucekDepartment of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Iveta SelingerovaDepartment of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechia.
Martina PodborskaDepartment of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czechia.
Alena KorberovaDepartment of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czechia.
Alena MikuskovaDepartment of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czechia.
Jiri StarhaDepartment of Pediatrics, Pediatric Nephrology Unit, University Hospital Brno, Brno, Czechia.
Miroslava BenovskaDepartment of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czechia.
Martin RadinaResearch Unit for Rare Diseases, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czechia.
Michal RichterSpadia Laboratories, Central Reference Lab, Division of Clinical Biochemistry, Ostrava, Czechia.
Lenka Zdrazilova DubskaDepartment of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechia.
Dalibor ValikDepartment of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Assessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference. Methods: Real-time clinical evaluation of an enzyme method (Roche CREP2) in comparison with the Jaffé gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023, we analyzed 8,498 patient samples, where 5,524 were heavily medicated STAT patient specimens, 500 were pediatric specimens, and 2,474 were from a distant general population in a different region using the same methods. Results: In 109 out of 5,524 hospital specimens (1.97%, Conclusion: In a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.

Indexed as

creatininecystatin CeGFRrenal functionsurgent care medication

Identifiers

PMID38259831
PMCPMC10801230

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