Evidence map›Paper›PMID 38259495›Full record

ArticleFrontiers in immunology2023

Macrophage SREBP1 regulates skeletal muscle regeneration.

Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Hyeree Kim, Takashi Matsuzaka and 4 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Loss ofiScience · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Yumiko Oishi *Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroyuki Koike *Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Naoki Kumagami *Department of Biochemistry & Molecular Biology, Nippon Medical School, Tokyo, Japan.
Yoshimi NakagawaDivision of Complex Bioscience Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Masaya ArakiDivision of Complex Bioscience Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Yoshitaka TaketomiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshimi MikiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shigeru MatsudaDepartment of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Hyeree KimDepartment of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Takashi MatsuzakaDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Hitoshi OzawaDepartment of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Hitoshi ShimanoDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Makoto MurakamiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ichiro ManabeDepartment of Systems Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Nippon Medical School · JPThe University of Tokyo · JPUniversity of Tsukuba · JPChiba University · JPTokyo Medical and Dental University · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages are essential for the proper inflammatory and reparative processes that lead to regeneration of skeletal muscle after injury. Recent studies have demonstrated close links between the function of activated macrophages and their cellular metabolism. Sterol regulatory element-binding protein 1 (SREBP1) is a key regulator of lipid metabolism and has been shown to affect the activated states of macrophages. However, its role in tissue repair and regeneration is poorly understood. Here we show that systemic deletion of

Indexed as

MacrophagesMuscle, SkeletalSterol Regulatory Element Binding Protein 1AnimalsMicePhospholipidsRegenerationPhospholipidsSrebf1 protein, mouseSterol Regulatory Element Binding Protein 1EPA - 20:5n-3fatty acid metabolismmacrophageskeletal muscle regenerationSREBP (sterol regulatory element-binding protein) pathway

Identifiers

PMID38259495
PMCPMC10800357
OpenAlexW4390665865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.