Evidence map›Paper›PMID 38259450›Full record

ArticleFrontiers in immunology2023

Single-cell profiling of CD11c+ B cells in atherosclerosis.

Tanyaporn Pattarabanjird, Prasad Srikakulapu, Brett Ransegnola, Melissa A Marshall, Yanal Ghosheh, Rishab Gulati, Chistopher Durant, Fabrizio Drago, Angela M Taylor, Klaus Ley and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tanyaporn PattarabanjirdCarter Immunology Center, University of Virginia, Charlottesville, VA, United States.
Prasad SrikakulapuCarter Immunology Center, University of Virginia, Charlottesville, VA, United States.
Brett RansegnolaCarter Immunology Center, University of Virginia, Charlottesville, VA, United States.
Melissa A MarshallCarter Immunology Center, University of Virginia, Charlottesville, VA, United States.
Yanal GhoshehLa Jolla Institute for Immunology, La Jolla, CA, United States.
Rishab GulatiLa Jolla Institute for Immunology, La Jolla, CA, United States.
Chistopher DurantLa Jolla Institute for Immunology, La Jolla, CA, United States.
Fabrizio DragoCarter Immunology Center, University of Virginia, Charlottesville, VA, United States.
Angela M TaylorCardiovascular Research Center, University of Virginia, Charlottesville, VA, United States.
Klaus LeyImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Coleen A McNamaraCarter Immunology Center, University of Virginia, Charlottesville, VA, United States.
University of Virginia · USCarter Center · USLa Jolla Institute for Immunology · USAugusta University Health · US

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
NHLBI NIH HHS P01 HL136275NIAID NIH HHS T32 AI007496
6 · The paper itself

Abstract

Circulating CD11c+ B cells, a novel subset of activated B cells, have been linked to autoimmunity and shown to expand with age. Atherosclerosis is an age-associated disease that involves innate and adaptive immune responses to modified self-antigens. Yet, the expression of CD11c on specific B-cell subtypes and its link to atherosclerosis are poorly understood. In this study, we characterized the frequency of CD11c+ B cells in tissues in mice with aging. We observed an age-associated increase in CD11c+ B cells in the spleen and bone marrow of ApoE

Indexed as

AtherosclerosisCoronary Artery DiseasePlaque, AtheroscleroticAgingAnimalsAortaHumansMiceagingautoimmunityB cellsCITESeqcoronary artery disease

Identifiers

PMID38259450
PMCPMC10800418
OpenAlexW4390665818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.