Noise robustness and metabolic load determine the principles of central dogma regulation.

Teresa W Lo, Han James Choi, Dean Huang, Paul A Wiggins

Abstract readPreprint

In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Updated by
Noise robustness and metabolic load determine the principles of central dogma regulation.2024

5 · Who and what money

Authors and funding

4 authors.

Teresa W LoDepartment of Physics, University of Washington, Seattle, Washington 98195, USA.

Han James ChoiDepartment of Physics, University of Washington, Seattle, Washington 98195, USA.

Dean HuangDepartment of Physics, University of Washington, Seattle, Washington 98195, USA.

Paul A WigginsDepartment of Physics, University of Washington, Seattle, Washington 98195, USA.

Funding

Replication resolved in the living cell: Replisome dynamics, stability and structure.R01GM128191 · NIGMS · VANDERBILT UNIVERSITY · PI MERRIKH, HOURA, WIGGINS, PAUL A · 2018 to 2021

$1.4M

NIGMS NIH HHS R01 GM128191

6 · The paper itself

Abstract

The processes of gene expression are inherently stochastic, even for essential genes required for growth. How does the cell maximize fitness in light of noise? To answer this question, we build a mathematical model to explore the trade-off between metabolic load and growth robustness. The model predicts novel principles of central dogma regulation: Optimal protein expression levels for many genes are in vast overabundance. Essential genes are transcribed above a lower limit of one message per cell cycle. Gene expression is achieved by load balancing between transcription and translation. We present evidence that each of these novel regulatory principles is observed. These results reveal that robustness and metabolic load determine the global regulatory principles that govern gene expression processes, and these principles have broad implications for cellular function.

Identifiers

PMID38259345

PMCPMC10802679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.