Evidence map›Paper›PMID 38259087›Full record

ArticleAntimicrobial agents and chemotherapy2024

Genetic complexity alters drug susceptibility of asexual and gametocyte stages of

Nicola Greyling, Mariëtte van der Watt, Hazel Gwarinda, Ashleigh van Heerden, Bryan Greenhouse, Didier Leroy, Jandeli Niemand, Lyn-Marié Birkholtz

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicola GreylingDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.ORCID 0000-0003-3579-7251
Mariëtte van der WattInstitute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.
Hazel GwarindaDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.
Ashleigh van HeerdenDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.
Bryan GreenhouseDepartment of Medicine, University of California-San Francisco, San Francisco, California, USA.ORCID 0000-0003-0287-9111
Didier LeroyMedicines for Malaria Venture, Geneva, Switzerland.
Jandeli NiemandDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.
Lyn-Marié BirkholtzDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.ORCID 0000-0001-5888-2905

Funding

Mentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6M
Translational Studies of Plasmodium Falciparum Infection DynamicsK23AI076614 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENHOUSE, BRYAN R · 2008 to 2012
$609k
Medicines for Malaria Venture (MMV) RD-19-001NIAID NIH HHS K23 AI076614NIAID NIH HHS K24 AI144048South African Medical Research Council (SAMRC)South African National Research Foundation UID 84627
6 · The paper itself

Abstract

Malaria elimination requires interventions able to target both the asexual blood stage (ABS) parasites and transmissible gametocyte stages of

Indexed as

AntimalarialsFolic Acid AntagonistsMalariaMalaria, FalciparumHumansPlasmodium falciparumAntimalarialsFolic Acid Antagonistsclinical isolatesdifferential compound sensitivitygametocytesgenetic diversitymalariaPlasmodium falciparum

Identifiers

PMID38259087
PMCPMC10916389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.