Evidence map›Paper›PMID 38259029›Full record

ArticleACS infectious diseases2024

How do Antimicrobial Peptides Interact with the Outer Membrane of Gram-Negative Bacteria? Role of Lipopolysaccharides in Peptide Binding, Anchoring, and Penetration.

Justus C Stephani, Luca Gerhards, Bishoy Khairalla, Ilia A Solov'yov, Izabella Brand

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Artificial intelligence catalyzes antimicrobial peptide design.Synthetic and systems biotechnology · 2027
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Enhancing the Antibacterial Activity of Endolysin againstJournal of microbiology and biotechnology · 2026
    Article
  8. Immunometabolic Reprogramming by Black Soldier Fly (Animals : an open access journal from MDPI · 2026
    Review
  9. The KW18 peptide acts as a dual antimicrobial and immunomodulatory therapeutic candidate in the context of antimicrobial resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  10. Review
  11. Article
  12. Review
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  14. Article
  15. Article
  16. Article
  17. Therapeutic Bioactivity Exerted by theMolecules (Basel, Switzerland) · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Justus C StephaniInstitute of Physics, Carl von Ossietzky University of Oldenburg, 26111 Oldenburg, Germany.
Luca GerhardsInstitute of Physics, Carl von Ossietzky University of Oldenburg, 26111 Oldenburg, Germany.ORCID 0000-0002-8404-2421
Bishoy KhairallaDepartment of Chemistry, Carl von Ossietzky University of Oldenburg, 26111 Oldenburg, Germany.ORCID 0000-0002-5841-739X
Ilia A Solov'yovInstitute of Physics, Carl von Ossietzky University of Oldenburg, 26111 Oldenburg, Germany.ORCID 0000-0002-8626-145X
Izabella BrandDepartment of Chemistry, Carl von Ossietzky University of Oldenburg, 26111 Oldenburg, Germany.ORCID 0000-0002-7710-0021
Carl von Ossietzky Universität Oldenburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacteria possess a complex structural cell envelope that constitutes a barrier for antimicrobial peptides that neutralize the microbes by disrupting their cell membranes. Computational and experimental approaches were used to study a model outer membrane interaction with an antimicrobial peptide, melittin. The investigated membrane included di[3-deoxy-d-manno-octulosonyl]-lipid A (KLA) in the outer leaflet and 1-palmitoyl-2-oleoyl-

Indexed as

Antimicrobial PeptidesLipopolysaccharidesGram-Negative BacteriaMelittenPeptidesAntimicrobial PeptidesLipopolysaccharidesMelittenPeptidesantimicrobial peptidesGram-negative bacteriainfrared spectroscopylipid–peptide interactionmolecular modelingouter membranespectroelectrochemistry

Identifiers

PMID38259029
PMCPMC10862549
OpenAlexW4391135744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.