Evidence map›Paper›PMID 38258487›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

NADPH oxidase 1 promotes hepatic steatosis in obese mice and is abrogated by augmented skeletal muscle mass.

Sebastian Larion, Caleb A Padgett, James D Mintz, Jennifer A Thompson, Joshua T Butcher, Eric J Belin de Chantemèle, Stephen Haigh, Sandeep Khurana, David J Fulton, David W Stepp

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sebastian LarionVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Caleb A PadgettVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0003-1046-344X
James D MintzVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Jennifer A ThompsonDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-0421-3719
Joshua T ButcherVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0002-7341-1949
Eric J Belin de ChantemèleVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0002-0184-3830
Stephen HaighVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Sandeep KhuranaDivision of Gastroenterology, Geisinger Health System, Danville, Pennsylvania, United States.
David J FultonVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0002-1528-1517
David W SteppVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0003-0184-8321
Augusta University · USGeisinger Health System · USUniversity of Calgary · CA

Funding

Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Sex and Leptin control of endothelial cell glycolysis and redox balance in Type 1 DiabetesP01HL160557 · NHLBI · AUGUSTA UNIVERSITY · PI Masuko Ushio-Fukai · 2024 to 2026
$9.0M
Circadian origins of vascular disease in obesityR01HL147159 · NHLBI · AUGUSTA UNIVERSITY · PI FULTON, DAVID J, STEPP, DAVID W · 2019 to 2022
$2.7M
Mechanism of cardiovascular disease in premenopausal womenR01HL155265 · NHLBI · AUGUSTA UNIVERSITY · PI BELIN DE CHANTEMELE, ERIC J · 2021 to 2024
$2.1M
Leptin in HIV associated vascular diseasesR01HL147639 · NHLBI · AUGUSTA UNIVERSITY · PI BELIN DE CHANTEMELE, ERIC J · 2020 to 2023
$2.0M
Skeletal Muscle as a Target for Cardio-Metabolic Disease in Sarcopenic ObesityK01AG064121 · NIA · OKLAHOMA STATE UNIVERSITY STILLWATER · PI BUTCHER, JOSHUA THOMAS · 2020 to 2024
$644k
Metabolic risk factors for vascular disease throughout the lifespanK99HD087527 · NICHD · AUGUSTA UNIVERSITY · PI THOMPSON, JENNIFER ANNE · 2016 to 2017
$171k
Glycemic Origins of Endothelial DysfunctionF31HL154646 · NHLBI · AUGUSTA UNIVERSITY · PI PADGETT, CALEB A · 2020 to 2021
$73k
NHLBI NIH HHS F31 HL154646NHLBI NIH HHS P01 HL160557NHLBI NIH HHS R01 HL147159NHLBI NIH HHS R01 HL147639NHLBI NIH HHS R01 HL155265NIA NIH HHS K01 AG064121NICHD NIH HHS K99 HD087527NIDDK NIH HHS U24 DK059637
6 · The paper itself

Abstract

Exercise as a lifestyle modification is a frontline therapy for nonalcoholic fatty liver disease (NAFLD), but how components of exercise attenuate steatosis is unclear. To uncouple the effect of increased muscle mass from weight loss in obesity, myostatin knockout mice were bred on a lean and obese

Indexed as

Non-alcoholic Fatty Liver DiseaseAnimalsHumansInsulinLiverMiceMice, KnockoutMice, ObeseMuscle, SkeletalMyostatinNADPH Oxidase 1NADPH OxidasesObesitySuperoxidesInsulinMyostatinNADPH Oxidase 1NADPH OxidasesNOX1 protein, mouseSuperoxidesmyostatinNAFLDNOX1PTP1BSREBPSREBP1

Identifiers

PMID38258487
PMCPMC11211036
OpenAlexW4391141610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.