ArticleEpilepsia open2024
Multimodal non-invasive evaluation in MRI-negative epilepsy patients.
Article in Epilepsia open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Multimodal machine learning for surgical decision support in epilepsy: Current evidence and translational gaps.Epilepsia · 2026Pooled it
- Diagnostic performance of neuroimaging modalities for epileptogenic focus localization: A systematic review.Epilepsia open · 2026Pooled it
- [BMC neurology · 2026Article
- Multimodal quantitative analysis guides precise preoperative localization of epilepsy.Journal of neurology · 2025Review
- Combined MRI morphometry and source imaging guide placement of stereo-EEG electrodes in focal epilepsy with subtle or absent lesions.Frontiers in neurology · 2025Article
- MEG in MRI-Negative Patients with Focal Epilepsy.Journal of clinical medicine · 2024Review
- Multimodal non-invasive evaluation in MRI-negative epilepsy patients.Epilepsia open · 2024Article
- Contribution of ictal-interictal SPECT and SISCOM to preoperative localization of the epileptogenic zone in frontal lobe epilepsy.Radiologia brasileiraReview
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Presurgical evaluation is still challenging for MRI-negative epilepsy patients. As non-invasive modalities are the easiest acceptable and economic methods in determining the epileptogenic zone, we analyzed the localization value of common non-invasive methods in MRI-negative epilepsy patients. In this study, we included epilepsy patients undergoing presurgical evaluation with presurgical negative MRI. MRI post-processing was performed using a Morphometric Analysis Program (MAP) on T1-weighted volumetric MRI. The relationship between MAP, magnetoencephalography (MEG), scalp electroencephalogram (EEG), and seizure outcomes was analyzed to figure out the localization value of different non-invasive methods. Eighty-six patients were included in this study. Complete resection of the MAP-positive regions or the MEG-positive regions was positively associated with seizure freedom (p = 0.028 and 0.007, respectively). When an area is co-localized by MAP and MEG, the resection of the area was significantly associated with seizure freedom (p = 0.006). However, neither the EEG lateralization nor the EEG localization showed statistical association with the surgical outcome (p = 0.683 and 0.505, respectively). In conclusion, scalp EEG had a limited role in presurgical localization and predicting seizure outcome, combining MAP and MEG results can significantly improve the localization of epileptogenic lesions and have a positive association with seizure-free outcome. PLAIN LANGUAGE SUMMARY: Due to the lack of obvious structure abnormalities on neuroimaging examinations, the identification of epilepsy lesions in MRI-negative epilepsy patients can be difficult. In this study, we intended to use non-invasive examinations to explore the potential epileptic lesions in MRI-negative epilepsy patients and to determine the results accuracy by comparing the neuroimaging results with the epilepsy surgery outcomes. A total of 86 epilepsy patients without obvious structure lesions on MRI were included, and we found that the combinations of different non-invasive examinations and neuroimaging post-processing methods are significantly associated with the seizure freedom results of epilepsy surgery.
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