Evidence map›Paper›PMID 38258109›Full record

ArticlePharmaceutics2024

3D-Printed Alginate/Pectin-Based Patches Loaded with Olive Leaf Extracts for Wound Healing Applications: Development, Characterization and In Vitro Evaluation of Biological Properties.

Francesco Patitucci, Marisa Francesca Motta, Marco Dattilo, Rocco Malivindi, Adele Elisabetta Leonetti, Giuseppe Pezzi, Sabrina Prete, Olga Mileti, Domenico Gabriele, Ortensia Ilaria Parisi and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesco PatitucciDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.ORCID 0000-0001-5165-8185
Marisa Francesca MottaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.
Marco DattiloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.ORCID 0009-0001-8607-016X
Rocco MalivindiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.ORCID 0000-0002-8313-2492
Adele Elisabetta LeonettiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.ORCID 0009-0006-0322-0596
Giuseppe PezziDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.
Sabrina PreteDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.
Olga MiletiDepartment of Information, Modeling, Electronics and System Engineering, University of Calabria, 87036 Rende, CS, Italy.
Domenico GabrieleDepartment of Information, Modeling, Electronics and System Engineering, University of Calabria, 87036 Rende, CS, Italy.ORCID 0000-0001-6962-5648
Ortensia Ilaria ParisiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.ORCID 0000-0002-2556-9864
Francesco PuociDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.ORCID 0000-0002-5963-6762

Funding

National Plan for NRRP Complementary Investments (PNC, established with the decree-law 6 May 2021, n. 59, converted by law n. 101 of 2021) in the call for the funding of research initiatives for technologies and innovative trajectories in the health and c project n. PNC0000003-AdvaNced Technologies for Human-centrEd Medicine (project acronym: ANTHEM)PON "Ricerca e Innovazione" 2014-2020, Asse IV "Istruzione e ricerca per il recupero" Azione IV.4-"Dottorati e contratti di ricerca su tematiche dell'innovazione"
6 · The paper itself

Abstract

Traditional wound dressings may lack suitability for diverse wound types and individual patient requirements. In this context, this study aimed to innovate wound care by developing a 3D-printed patch using alginate and pectin and incorporating Olive Leaf Extract (OLE) as an active ingredient. Different polymer-to-plasticizer ratios were systematically examined to formulate a printable ink with optimal viscosity. The resultant film, enriched with OLE, exhibited a substantial polyphenolic content of 13.15 ± 0.41 mg CAE/g, showcasing significant antioxidant and anti-inflammatory properties. Notably, the film demonstrated potent scavenging abilities against DPPH, ABTS, and NO radicals, with IC

Indexed as

3D printingalginatebiocompatibilityhuman cell line activation test (h-CLAT)olive leaf extracts (OLEs)patchespectinscratch assaywound healingwound management

Identifiers

PMID38258109
PMCPMC10819698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.