Evidence map›Paper›PMID 38258083›Full record

ArticlePharmaceutics2024

New Formulation-Microporation Combination Approaches to Delivering Ciclopirox across Human Nails.

Juliana Kishishita, Camila de Almeida Perez Pimenta, Danielle Patricia Cerqueira Macedo, M Begoña Delgado-Charro, Leila Bastos Leal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Juliana KishishitaDepartamento de Ciências Farmacêuticas, Núcleo de Desenvolvimento Farmacêutico e Cosmético (NUDFAC), Universidade Federal de Pernambuco (UFPE), Recife 50740-521, PE, Brazil.
Camila de Almeida Perez PimentaDepartamento de Ciências Farmacêuticas, Núcleo de Desenvolvimento Farmacêutico e Cosmético (NUDFAC), Universidade Federal de Pernambuco (UFPE), Recife 50740-521, PE, Brazil.
Danielle Patricia Cerqueira MacedoDepartamento de Ciências Farmacêuticas, Laboratório de Análises Microbiológicas (LAM), Universidade Federal de Pernambuco (UFPE), Recife 50740-521, PE, Brazil.
M Begoña Delgado-CharroDepartment of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, UK.ORCID 0000-0002-2233-7654
Leila Bastos LealDepartamento de Ciências Farmacêuticas, Núcleo de Desenvolvimento Farmacêutico e Cosmético (NUDFAC), Universidade Federal de Pernambuco (UFPE), Recife 50740-521, PE, Brazil.
Universidade Federal de Pernambuco · BRUniversity of Bath · GB

Funding

Academy of Medical Sciences NAF\R10\100041
6 · The paper itself

Abstract

Topical treatments for onychomycosis are of interest to those seeking to avoid systemic drug interactions and to improve systemic safety. This work aimed to develop aqueous-based, simple, and cost-effective vehicles that provide high solubility for ciclopirox and enable the delivery of an active through channels created by nail microporation. Following solubility tests, aqueous gels and thermogels based on hydroxypropylmethylcellulose and poloxamer 407, respectively, were loaded with 8% and 16% ciclopirox. Their performance was then compared to the marketed lacquer Micolamina

Indexed as

ciclopiroxgelMicolamina®microporationnailonychomycosisthermogelTrichophyton rubrum

Identifiers

PMID38258083
PMCPMC10819317
OpenAlexW4390587953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.