Improving Inhalation Performance with Particle Agglomeration via Combining Mechanical Dry Coating and Ultrasonic Vibration.

Qingzhen Zhang, Zheng Wang, Kaiqi Shi, Hang Zhou, Xiaoyang Wei, Philip Hall

Open access · goldAbstract read

In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

2.1field-weighted citation impact, top 12% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient-Free Dry Powder for Inhalation.Advances in pharmacological and pharmaceutical sciences · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Qingzhen ZhangDepartment of Chemical and Environmental Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.

Zheng WangDepartment of Chemical and Environmental Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.ORCID 0000-0002-0985-4868

Kaiqi ShiSuzhou Inhal Pharma Co., Ltd., Suzhou 215000, China.

Hang ZhouCollege of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.

Xiaoyang WeiNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo 315100, China.

Philip HallDepartment of Chemical and Environmental Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.ORCID 0000-0001-8681-3958

University of Nottingham Ningbo China · CNSuzhou Research Institute · CNZhejiang University of Technology · CN

Funding

Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute I01211200006Zhejiang Provincial Department of Science and Technology 2020E10018

6 · The paper itself

Abstract

Agglomerate formulations for dry powder inhalation (DPI) formed with fine particles are versatile means for the highly efficient delivery of budesonide. However, uncontrolled agglomeration induces high deposition in the upper airway, causing local side effects due to high mechanical strength, worse deagglomeration, and poor fine-particle delivery. In the present study, fine lactose was mechanically dry-coated prior to particle agglomeration, and the agglomerates were then spheroidized via ultrasonic vibration to improve their aerosol performance. The results showed that the agglomerate produced with the surface-enriched hydrophobic magnesium stearate and ultrasonic vibration demonstrated improved aerosolization properties, benefiting from their lower mechanical strength, less interactive cohesive force, and improved fine powder dispersion behavior. After dispersion utilizing a Turbuhaler

Indexed as

budesonideinhalationmagnesium stearatemechanical dry-coatingultrasonic vibration

Identifiers

PMID38258079

DOI10.3390/pharmaceutics16010068

PMCPMC10821125

OpenAlexW4390471276

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.