Evidence map›Paper›PMID 38258052›Full record

ArticlePharmaceutics2023

Anti-Inflammatory Effects of the LK5 Herbal Complex on LPS- and IL-4/IL-13-Stimulated HaCaT Cells and a DNCB-Induced Animal Model of Atopic Dermatitis in BALB/c Mice.

Hyun-Jeong Kim, So-Yeon Kim, Ho Jung Bae, Yu-Yeong Choi, Ju-Yeon An, Ye Eun Cho, So-Young Cho, Su-Jung Lee, Sanghyun Lee, MinSub Sin and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Marine drugs · 2026
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  9. International journal of molecular sciences · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Hyun-Jeong KimDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
So-Yeon KimDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.ORCID 0000-0003-1885-0540
Ho Jung BaeAgriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea.
Yu-Yeong ChoiDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Ju-Yeon AnDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Ye Eun ChoDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
So-Young ChoDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Su-Jung LeeDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Sanghyun LeeDepartment of Plant Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea.ORCID 0000-0002-0395-207X
MinSub SinLK Co., Ltd., Hwaseong 18469, Republic of Korea.
Young Min YunLK Co., Ltd., Hwaseong 18469, Republic of Korea.
Jong Ryul LeeLK Co., Ltd., Hwaseong 18469, Republic of Korea.
Se Jin ParkDepartment of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.ORCID 0000-0002-9370-5258
Kangwon National University · KR

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education NRF-2021R1A6A1A03044242National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) RS-2023-00242836
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease influenced by a complex interplay of genetic and environmental factors. The activation of the JAK-STAT pathway increases the expression of inflammatory cytokines such as IL-4 and IL-13, further deteriorating AD. Therefore, for the treatment of AD, the JAK-STAT pathway is emerging as a significant target, alongside inflammatory cytokines. This study investigates the potential therapeutic effects of a novel herbal complex, LK5, composed of

Indexed as

anti-inflammationatopic dermatitisitchingLK5 herbal complexsignal transducers and activators of transcription

Identifiers

PMID38258052
PMCPMC10821371
OpenAlexW4390272718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.