Evidence map›Paper›PMID 38258024›Full record

ArticleMicroorganisms2024

The Efficacy of a Mix of Probiotics (

Angela Saviano, Carmine Petruzziello, Clelia Cancro, Noemi Macerola, Anna Petti, Eugenia Nuzzo, Alessio Migneco, Veronica Ojetti

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Efficacy and Safety ofFood science & nutrition · 2025
    Article
  5. Review
  6. Comparative effectiveness of different therapies forThe Lancet regional health. Europe · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Angela SavianoEmergency Medicine Department, Polyclinic A. Gemelli Hospital, 00168 Rome, Italy.
Carmine PetruzzielloInternal Medicine Department, San Carlo di Nancy Hospital, 00165 Rome, Italy.ORCID 0000-0003-1025-1092
Clelia CancroInternal and Emergency Medicine Department, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Noemi MacerolaInternal Medicine Department, San Carlo di Nancy Hospital, 00165 Rome, Italy.
Anna PettiInternal Medicine Department, San Carlo di Nancy Hospital, 00165 Rome, Italy.
Eugenia NuzzoInternal Medicine Department, San Carlo di Nancy Hospital, 00165 Rome, Italy.
Alessio MignecoEmergency Medicine Department, Polyclinic A. Gemelli Hospital, 00168 Rome, Italy.
Veronica OjettiInternal and Emergency Medicine Department, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-8953-0707
Ospedale San Carlo · ITUniversità Cattolica del Sacro Cuore · ITAgostino Gemelli University Polyclinic · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibiotic-associated diarrhea is a condition reported in 5-35% of patients treated with antibiotics, especially in older patients with comorbidities. In most cases, antibiotic-associated diarrhea is not associated with serious complications, but it can prolong hospitalization and provoke

aimThe aim of this study was to test the efficacy of a mix of two probiotic strains ( PATIENTS AND

methodsWe enrolled 113 (49M/64F, mean age 69.58 ± 21.28 years) adult patients treated with antibiotics who were hospitalized at the Internal Medicine Department of the San Carlo di Nancy Hospital in Rome from January 2023 to September 2023. Patients were randomized to receive probiotics 1.4 g twice/day in addition with antibiotics (Reuterin GG

resultsPatients treated with Reuterin GG

conclusionsOur study showed, for the first time, the efficacy of these two specific probiotic strains in preventing antibiotic-associated diarrhea and clostridium difficile infection in adult hospitalized patients treated with antibiotic therapy. This result allows us to hypothesize that the use of specific probiotic strains during antibiotic therapy can prevent dysbiosis and subsequent antibiotic-associated diarrhea and clostridium difficile infection, thus resulting in both patient and economic health care benefits.

Indexed as

antibioticdiarrheaLacticaseibacillus rhamnosus GG ATCC 53103Limosilactobacillus reuteri LMG P-27481probiotic

Identifiers

PMID38258024
PMCPMC10819176
OpenAlexW4390986625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.