Evidence map›Paper›PMID 38257948›Full record

ReviewMicroorganisms2024

The Evolving Microbiome of Dental Caries.

Grace Spatafora, Yihong Li, Xuesong He, Annie Cowan, Anne C R Tanner

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 7 pooled it
76.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 7 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. The association between self-reported vaping and the human oral microbiome: a systematic review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Pooled it
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  6. Key virulence genes associated withFrontiers in oral health · 2025
    Pooled it
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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Grace SpataforaBiology and Program in Molecular Biology and Biochemistry, Middlebury College, Middlebury, VT 05753, USA.ORCID 0000-0003-2043-4853
Yihong LiDepartment of Public and Ecosystem Health, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-5476-1943
Xuesong HeADA-Forsyth Institute, Cambridge, MA 02142, USA.
Annie CowanThe Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.ORCID 0000-0002-5458-0843
Anne C R TannerADA-Forsyth Institute, Cambridge, MA 02142, USA.ORCID 0000-0002-1331-9163
Cornell University · USMayo Clinic · USMiddlebury College · US

Funding

Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Investigating SloR virulence gene metalloregulation in Streptococcus mutansR01DE014711 · NIDCR · MIDDLEBURY COLLEGE · PI SPATAFORA, GRACE A. · 2004 to 2021
$4.1M
Making a quantum leap in plaque research with modern sciencesR01DE020102 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2010 to 2020
$3.7M
Preventing dental caries through targeted treatment of acid-producing bacteriaR01DE029479 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI HE, XUESONG, SUN, JIRUN · 2021 to 2025
$3.7M
Diversity of Lactobacilli Associated with Severe Early Childhood CariesR01DE019455 · NIDCR · NEW YORK UNIVERSITY · PI CAUFIELD, PAGE W, LI, YIHONG · 2011 to 2014
$2.5M
Host tRNA-derived small RNAs (tsRNAs) mediate interactions between host and oral microbesR01DE030943 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Xuesong He · 2022 to 2026
$2.4M
Studying the Protective Effects of Normal Oral FloraR01DE026186 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2016 to 2020
$2.1M
NIDCR NIH HHS R01 DE014711NIDCR NIH HHS R01 DE019455NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE029479NIDCR NIH HHS R01 DE030943NIH HHS DE014711NIH HHS DE019455NIH HHS DE020102NIH HHS DE023810NIH HHS DE026186
6 · The paper itself

Abstract

Dental caries is a significant oral and public health problem worldwide, especially in low-income populations. The risk of dental caries increases with frequent intake of dietary carbohydrates, including sugars, leading to increased acidity and disruption of the symbiotic diverse and complex microbial community of health. Excess acid production leads to a dysbiotic shift in the bacterial biofilm composition, demineralization of tooth structure, and cavities. Highly acidic and acid-tolerant species associated with caries include

Indexed as

cariesecologymicrobiologyStreptococcus mutanstreatment

Identifiers

PMID38257948
PMCPMC10819217
OpenAlexW4390669122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.