Evidence map›Paper›PMID 38257892›Full record

ArticleMicroorganisms2023

BKPyV DNAemia in Kidney Transplant Recipients Undergoing Regular Screening: A Single-Centre Cohort Study.

Daniel B Rasmussen, Dina L Møller, Sebastian R Hamm, Álvaro H Borges, Alex C Y Nielsen, Nikolai S Kirkby, Søren S Sørensen, Susanne D Nielsen

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07407673 (Prediction and Prevention of Bloodstream Infections After Kidney Transplantation - The PREDICT Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07407673 phase3not yet recruitingnot on this mapstarted 2027, after this paper: background citation

Prediction and Prevention of Bloodstream Infections After Kidney Transplantation - The PREDICT Study

TypeinterventionalSponsorSusanne Dam Nielsen, MD, DMScRan2027 to 2041Enrolled180ConditionsKidney Transplant Infection, Bloodstream Infection, Kidney Transplant, Kidney Transplant RecipientsArmsPivmecillinam, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel B RasmussenViro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0003-1496-8859
Dina L MøllerViro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-3909-0643
Sebastian R HammViro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-2583-3442
Álvaro H BorgesDepartment of Infectious Disease Immunology, Statens Serum Institut, 2300 Copenhagen, Denmark.
Alex C Y NielsenDepartment of Clinical Microbiology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0003-3426-0014
Nikolai S KirkbyDepartment of Clinical Microbiology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Søren S SørensenDepartment of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0001-5898-8048
Susanne D NielsenViro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
University of Copenhagen · DKStatens Serum Institut · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection with BK polyomavirus (BKPyV) is a common opportunistic infection after kidney transplantation (KT) and may affect graft function. We aimed to determine the incidence, risk factors, and clinical outcomes of BKPyV DNAemia in a prospective cohort of 601 KT recipients transplanted from 2012 to 2020. BKPyV PCR on plasma was performed at days 60, 90, 180, 270, and 360 post-KT. Any BKPyV DNAemia was defined as a single BKPyV DNA of ≥1000 copies/mL. Severe BKPyV DNAemia was defined as two consecutive BKPyV DNA of ≥10,000 copies/mL. Cumulative incidences were investigated using the Aalen-Johansen estimator, and the risk factors were investigated in Cox proportional hazard models. The incidence of any BKPyV DNAemia and severe BKPyV DNAemia was 21% (18-25) and 13% (10-16) at one year post-KT, respectively. Recipient age > 50 years (aHR, 1.72; 95% CI 1.00-2.94;

Indexed as

BKPyV DNAemiaBK viremiacohort studygraft functiongraft lossimmunosuppressionkidney transplantopportunistic infection

Identifiers

PMID38257892
PMCPMC10819282
OpenAlexW4390395277

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.