ReviewMicroorganisms2023
The Viable but Non-Culturable (VBNC) State, a Poorly Explored Aspect of Beneficial Bacteria.
Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Temperature, Disinfectant Concentration and Bacterial Innate Properties Influence the Disinfection of Bacterial Pathogens Relevant to Catfish Aquaculture.Journal of fish diseases · 2026Article
- Seasonal Baseline Evaluation of Physicochemical Parameters and Culturable Bacterial Characteristics in Northwestern Himalayan Ramsar Sites.Environmental microbiology reports · 2026Article
- From Rhizosphere to Resistance: Microbe-Plant Interactions in Eco-Smart Biocontrol.MicrobiologyOpen · 2026Review
- Microbial Survival, Sublethal Injury, and Recovery in Frozen Food Systems: Implications for Safety, Quality Deterioration, and Cold-Chain Control.Comprehensive reviews in food science and food safety · 2026Review
- Rapid efficacy testing of cattle footbath disinfectants by flow cytometry: a laboratory-validated screening method complementary to EN 1656.Journal of veterinary research · 2026Article
- Plasma-Treated Water (PTW) Delaying the Lag Phase of Food-Related Pathogens.Microorganisms · 2026Article
- Transcriptomic insights on differential gene regulations in viable but non-culturable (VBNC) bacteria under chlorine and UV disinfection.BMC microbiology · 2026Article
- QIAstat-Dx Syndromic Molecular Testing Versus Conventional Diagnostics in Acute Gastroenteritis: Impact on Pathogen Detection and Laboratory Workflow.Microorganisms · 2026Article
- Environmental Application of Newly Designed Loop-Mediated Isothermal Amplification (LAMP) Kits for Nosocomial Pathogen Detection in Hospital Settings.Life (Basel, Switzerland) · 2026Article
- Article
- Revisiting Strategies for Bacterial Enumeration: The Case for Viable but Nonculturable (VBNC) Cells in Supplement Products.Probiotics and antimicrobial proteins · 2026Review
- Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases.MicrobiologyOpen · 2026Review
- Untargeted Metabolomics Reveals Metabolic Reprogramming During Viable but Non-Culturable State Formation inFoods (Basel, Switzerland) · 2026Article
- Growth phase-specific induction of a viable but nonculturable (VBNC) state inMicrobiology spectrum · 2026Article
- Nitrogen-Controlled Host Gatekeeping: Regulatory Chokepoints Across Four Windows for Diazotroph Access.International journal of molecular sciences · 2026Article
- Optimization of the microbiological quality control validation of corneal medium using a clinical C. acnes isolate.Cell and tissue banking · 2026Article
- Stress-Driven Tolerance and Persistence ofBiology · 2026Review
- Improving Microbiological Monitoring of Hospital Surfaces: Loop-Mediated Isothermal Amplification (LAMP) as a New Approach for Rapid Nosocomial Pathogens Detection.International journal of environmental research and public health · 2026Article
- Evaluating the Quality of Selected Commercial Probiotic Products, Both Dietary Supplements and Foods for Special Medical Purposes.Foods (Basel, Switzerland) · 2026Article
- Surface scan cold plasma technology for effective inhibition of Staphylococcus epidermidis and Escherichia coli.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Many bacteria have the ability to survive in challenging environments; however, they cannot all grow on standard culture media, a phenomenon known as the viable but non-culturable (VBNC) state. Bacteria commonly enter the VBNC state under nutrient-poor environments or under stressful conditions. This review explores the concept of the VBNC state, providing insights into the beneficial bacteria known to employ this strategy. The investigation covers different chemical and physical factors that can induce the latency state, cell features, and gene expression observed in cells in the VBNC state. The review also covers the significance and applications of beneficial bacteria, methods of evaluating bacterial viability, the ability of bacteria to persist in environments associated with higher organisms, and the factors that facilitate the return to the culturable state. Knowledge about beneficial bacteria capable of entering the VBNC state remains limited; however, beneficial bacteria in this state could face adverse environmental conditions and return to a culturable state when the conditions become suitable and continue to exert their beneficial effects. Likewise, this unique feature positions them as potential candidates for healthcare applications, such as the use of probiotic bacteria to enhance human health, applications in industrial microbiology for the production of prebiotics and functional foods, and in the beer and wine industry. Moreover, their use in formulations to increase crop yields and for bacterial bioremediation offers an alternative pathway to harness their beneficial attributes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.